NanoActive™ ALA (리포좀 티옥틱애씨드)

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[Nano-Lipoic Acid (NanoActive ALA)] Nanoactive ALA is a new type of lipoic acid nanoliposome preparation (NanoLiposomal ALA). Product Name: Nano Liposomal ALA; Nanoactive ALA; BioaActive ALA; BioActive Alpha lipoic acid; NanoActive Alpha lipoic acid; Soluble alpha lipoic acid; Soluble ALA CAS: 62-46-4 Description: Alpha lipoic acid is an enzyme existing in mitochondria, which is similar to vitamins and can  eliminate free radicals that accelerate aging and cause disease. Lipoic acid has both fat-soluble and water-soluble properties, so it can pass through the entire body and reach every cell, providing comprehensive performance for human body. It is an all-purpose antioxidant with fat solubility and water solubility. Lipoic acid has the antioxidant effects 400 times greater than that of vitamins C and E, and it can greatly enhance the effects of vitamins C and E. Also, its efficacy lasts longer than other antioxidants. Smaller than the molecules of vitamin E, it can be easily absorbed by the skin and be effective in beautifying, activating cells and facilitating hair growth. Lipoic acid is effective in removing dark eye circles, wrinkles and spots. In addition, it enhances metabolism, improving the body's blood circulation, so that skill will no longer be dull and the appearance or pores will be minimized, making your skin enviously firm and delicate. Therefore, lipoic acid is also an anti-aging nutrient that ranks the first place in the United States, which ties with ALA. The lipoic acid nanoactive material with particle size less than 30nm developed by nano-transmission system (NDS) completely solves the problem of solubility, and allows lipoic acid to be stably encapsulated in nano-carriers, which can greatly increase its absorption efficiency and bioavailability. Lipoic acid’s structure Lipoic acid is an powerful versatile anti-oxidant that can regenerates other antioxidants. Lipoic acid (LA) target against skin aging Features NanoActive ALA uses FDA GRAS grade materials for high safety. NanoActive ALA has good heat, pH and shear stability and is easy to use NanoActive ALA greatly improves ALA’s stability and bioavailability NanoActive ALA improves the stability and absorption of other actives in the product. NanoActive ALA is 100% water soluble and 100% oil soluble (amphiphilic) for a wide range of applications. Efficacy NanoActive ALA can enhance the anti-oxidation effect of skin cells, reduce the damage from free radicals to the skin, significantly reduce skin roughness, eliminate freckles and reduce the appearance of fine lines. NanoActive ALA is an active functional ingredient that is effective in anti-wrinkles, whitening, anti-aging, moisturizing and increasing skin elasticity. It helps to enhance the efficacy of antioxidants such as polyphenols and kinetin, and also reduces the endogenous antioxidants. Use: Add it at room temperature. You may heat it to above 40 °C to speed up its dissolution, Recommended dosage: 1-3%. Better effect with products containing lipoic acid. Storage: Keep it away from light at a temperature below 25°C. Experimental proof Effect of lipoic acid on cell activity Lipoic acid's whitening effect Lipoic acid’s anti-wrinkle effect [纳米包裹硫辛酸 NanoActive ALA] 硫辛酸（Alpha lipoic acid，ALA）是一种存在于线粒体中的酶，能消除导致加速老化与致病的自由基。ALA是兼具脂溶性与水溶性的万能抗氧化剂，具有400倍的维生素C和E的抗氧化作用。 ALA不仅对于皱纹、斑点、黑眼圈效能显著，而且其消炎作用能帮助祛痘祛疤、修复损伤。 抗老去皱 皮肤老化包括自然老化和光老化。自然老化导致表皮变薄、脆弱性增加、真皮厚度和血管减少、真皮成纤维细胞数量及合成能力降低。光老化会导致黑色素细胞聚集，弹性组织增生和真皮萎缩，并伴随胶原蛋白的流失。 硫辛酸可以提高人体真皮中成纤维细胞的增殖和胶原蛋白的表达，使得弹性增加，减少皱纹产生。 谷胱甘肽（GSH）是一种重要的水溶内源性抗氧化剂，在皮肤老化中起着重要作用。ALA可以显著提高GSH水平，ALA被细胞吸收，还原为DHLA，DHLA被分泌到细胞外介质中，将胱氨酸还原为半胱氨酸。半胱氨酸被细胞吸收的速度比胱氨酸快10倍，从而增强了GSH的生物合成。 ALA和DHLA在生物体内的相互转化和代谢再生过程中，能清除以下所有自由基。 美白淡斑 硫辛酸可以减少启动皮肤色素沉着过程的关键转录因子蛋白的表达，同时减少促进黑色素生成的酶。 硫辛酸可以减少黑色素的生成，且其对黑色素的抑制率高于维C。 消炎祛痘 痤疮（包括脓疱、丘疹、粉刺）是皮肤最常见的脓疱病，是一种影响皮肤毛囊皮脂单位的多因素疾病。 由于皮脂腺油脂分泌旺盛，毛囊皮脂腺开口处过度角化，感染痤疮丙酸杆菌，导致痤疮产生。在寻常痤疮的异常情况下，上皮脱落增加，死细胞堆积，刺激皮脂腺小叶外层分裂分化，引起痤疮超敏反应。 核因子NF-кB和激活蛋白1（AP-1）是两种重要的转录因子，当细胞处于氧化应激状态时，这些转录因子会被激活，产生促炎细胞因子，对细胞造成破坏。硫辛酸可以减少NF-кB和AP-1的产生，影响肿瘤坏死因子-α、白细胞介素（IL-1、IL-6、IL-8)等炎症细胞因子的表达。 祛疤修复 疤痕是由伤口愈合产生的，发生在三个不同的阶段：炎症、肉芽组织的形成和基质的形成。在第一阶段，伤口部位释放趋化因子产生的自由基会破坏细胞膜导致新胶原蛋白的形成。在第二阶段，巨噬细胞通过释放PDGF、TNF-α和EGF来诱导肉芽组织形成。最后角质形成细胞恢复正常分化形式并开始形成基质。 胶原蛋白的合成与沉积以及持续性炎症和纤维化会影响疤痕的产生。此外，AGEs会导致胶原纤维缩短、变薄、杂乱无章，从而降低弹性和皮肤厚度，同时增加收缩和延迟伤口闭合。 硫辛酸可以降低胶原蛋白和糖胺聚糖含量，减少疤痕产生，修复子宫损伤。 应用 由于硫辛酸配伍性差、容易析出、皮肤不易吸收、生物利用度低，浦瑞生物医药利用专有的新型纳米传输技术（NDS）制成纳米包裹硫辛酸（NanoActive ALA）。稳定性好、安全性高，配伍性好、适合各种配方，产品吸收效果好、生物利用度高。可以广泛应用于抗老去皱、美白淡斑、消炎抗敏、治疗痤疮、减少疤痕、修复损伤等产品，且对乳液膏霜配方、凝胶配方、水剂配方均兼容。 产品名称：纳米包裹硫辛酸，硫辛酸纳米脂质体，水溶性硫辛酸 Product Name：NanoActive ALA，ALA Nano-Liposome，Water-Soluble ALA ​ [纳米硫辛酸 Nanoactive ALA] 硫辛酸 (alpha lipoic acid) 是一种存在于线粒体的酶，类似维他命，能消除加速老化与致病的自由基。硫辛酸兼具脂溶性与水溶性的特性，因此可以在全身通行无阻，到达任何一个细胞部位，提供人体全面效能，是具脂溶性与水溶性的万能抗氧化剂。硫辛酸具有400倍的维生素C和E的抗氧化作用，而且硫辛酸还能大大增强维生素C和E的作用，且硫辛酸的作用力也比其它抗氧化剂来得持久。因此硫辛酸也是在美国与ALA并驾齐驱No.1的抗老化营养剂。利用纳米传输系统（NDS）开发的粒径小于30nm的硫辛酸纳米活性物，完全解决了硫辛酸溶解性问题，让硫辛酸稳定地包裹于纳米载体之中，能大幅增加吸收效率和生物利用度。 硫辛酸结构 硫辛酸是一种可以使其他抗氧化剂再生的万能强抗氧化剂 硫辛酸（LA）对抗皮肤老化作用靶标 产品特点 NanoActive ALA采用FDA GRAS级原料，安全性高 NanoActive ALA 对热、pH和剪切稳定性好，使用方便 NanoActive ALA大大提高了ALA的稳定性和生物利用度 NanoActive ALA能提高产品中其他活性物的稳定性并促进吸收 NanoActive ALA可100% 水溶亦100%油溶（两亲性），适用范围广 产品功效 有助于增强多酚(polyphenols)及激动素 (kinetin)等抗氧化物质作用，还能还原内源性抗氧化剂。 产品使用：室温下加入，加热至40℃以上可以加快溶解速度，推荐用量:1-3%。与硫辛酸等产品配合使用效果更好。 产品储存：25℃以下避光保存。 实验证明 硫辛酸对细胞活性的影响 硫辛酸美白效果 硫辛酸抗皱效果 纳米硫辛酸 （Nanoactive ALA）是一种新型的硫辛酸纳米脂质体制剂（NanoLiposomal ALA）。 中文名称：纳米脂质体硫辛酸；纳米包裹硫辛酸；水溶性硫辛酸；生物活性硫辛酸；纳米硫辛酸 Product Name：Nano Liposomal ALA;Nanoactive ALA;BioaActive ALA; BioActive Alpha lipoic acid; NanoActive Alpha lipoic acid;Soluble alpha lipoic acid;Soluble ALA CAS:62-46-4 Tagged 保湿, 减少细小皱纹, 抗氧化, 抗皱, 抗衰老, 消除雀斑, 美白.

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상품명

NanoActive™ ALA (리포좀 티옥틱애씨드)

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PuriPharm

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Actives

용도

Whitening/Brightening, Firming/Lifting

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NMPA

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공급사 (1)

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INCI

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CAS 번호

62-46-4

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Storage

Keep it away from light at a temperature below 25°C.