NanoActive™ RETINAMIDE

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[NanoActive RETINAMIDE] NanoActive RETINAMIDE is an innovative ingredient that combines the anti-aging benefits of retinamide with the advantages of nano-technology, designed to enhance skin penetration, stability, and bioavailability. Below is a detailed introduction to NanoActive RETINAMIDE: Chemical Characteristics NanoActive RETINAMIDE is a derivative of retinamide, created by conjugating retinoic acid with polyethylene glycol (PEG) to form a polyethoxylated retinoic acid. This structure significantly improves its water solubility, stability and skin permeability while reducing irritation and degradation potential. Functions and Benefits 2.1 Anti-Aging Effects Promotes Collagen Synthesis: NanoActive RETINAMIDE significantly increases collagen synthesis in the skin, reducing the appearance of wrinkles and fine lines. Reduces Elastin Degradation: By inhibiting the breakdown of elastin, it improves skin elasticity, making the skin firmer. Antioxidant Properties: It has antioxidant properties that combat free radical damage, delaying skin aging. 2.2 Skin Permeability NanoActive RETINAMIDE, through nano-encapsulation technology, significantly enhances skin absorption. Studies have shown that its skin permeability is several times higher than that of traditional retinol and retinyl palmitate. Its hydrophilic nature allows it to easily penetrate the skin barrier, reaching deeper skin layers to deliver anti-aging benefits. 2.3 Stability Amide Stability: To create a stable retinoic acid molecule, an amide condensation process is employed. In this chemical process, two molecules combine to form a new compound, creating a strong and highly stable bond known as an amide bond. This newly formed bond acts like a powerful adhesive, enhancing the stability of the original component. The amide structure inRETINAMIDE is highly stable and does not hydrolyze like retinoate (e.g., hydroxypinacolone retinoate, HPR), which can gradually convert to prohibited retinoic acid during the shelf life of cosmetic products. This makes NanoActive RETINAMIDE a safer and more stable alternative for long-term use. Environmental Stability: NanoActive RETINAMIDE exhibits higher stability under conditions of light, oxygen, and high temperatures, solving the problem of traditional retinamide being prone to degradation. Formulation Stability: In O/W emulsions, it shows superior stability compared to retinol and retinyl palmitate, making it ideal for various cosmetic formulations. Contribution of Polyethylene Glycol (PEG): PEG significantly enhances the stability and skin permeability of PuriActives® Liposomal RETINAMIDE. The hydrophilic nature of PEG makes the compound more soluble in water and easier to absorb into the skin, while also protecting the molecule from oxidation and degradation. This results in a more stable and effective product that can be conveniently used during the day. 2.4 Safety NanoActive RETINAMIDE has demonstrated excellent safety in various toxicological tests, with no irritation or sensitization, making it suitable for long-term use. It has passed allergy and skin irritation tests, proving to be gentle on the skin without causing redness or irritation. Combination with PuriActives®FastCalmin: Combined with the patented formula PuriActives®FastCalmin, it effectively prevents adverse reactions commonly associated with retinol-based ingredients, providing enhanced safety and tolerability. Applications 3.1 Core Anti-Aging Applications Anti-Wrinkle Serums– For reducing the appearance of wrinkles and fine lines. Firming Creams– To enhance skin elasticity and reduce sagging. Whitening Products– By promoting collagen synthesis, it helps to even out skin tone. Sunscreen and Repair Products– Enhances the skin's self-repair ability and reduces photo-aging damage. 3.2 Additional Applications Based on Tretinoin Clinical Efficacy All listed benefits are enabled by the ingredient’s high permeability, low irritation profile, and daylight stability. Indication Mechanism of Action Suitable Product Forms Acne vulgaris (comedonal & inflammatory) Regulates follicular keratinization, suppresses sebum production, exerts anti-inflammatory effects. Spot gels, oil-control serums, overnight blemish patches. Keratosis pilaris (chicken skin) Accelerates desquamation of hyper-keratotic follicular plugs, smoothes rough texture. Body lotions with 5–8 % urea + 1 % NanoActive RETINAMIDE Inhibits epidermal hyper-proliferation, restores orderly differentiation. Calming repair creams, scalp lotions under occlusion. Flat warts / HPV lesions Induces keratinocyte apoptosis, activates local immunity, assists wart clearance. Post-cryotherapy repair gels, low-irritation keratolytic pens. Hyper-pigmentation (melasma, post-inflammatory marks) Inhibits melanosome transfer, accelerates epidermal turnover, fades discoloration. Intensive pigment-correct serums, post-laser spot correctors. Photo-damage / actinic keratosis field therapy Repairs UV-induced collagen fragmentation, reduces actinic keratosis count. Antioxidant day creams with SPF, dermatologist-supervised field sprays. Ichthyosis & disorders of cornification Corrects defective desquamation, replenishes intercellular lipids. High-occlusion ointments for extremities, pediatric-friendly lotions. Post-procedure maintenance (laser, microneedling, chemical peel) Enhances re-epithelialization and collagen remodeling while minimizing retinoid irritation. Barrier-repair creams introduced 48 h post-procedure. Usage Recommendations Formulation Suggestions– Typically used in nighttime skincare products to avoid light exposure; daylight use is possible when combined with broad-spectrum SPF. Recommended Concentration– 1–5 %, adjustable according to product positioning. Packaging Suggestions– Use opaque, airless dispensers to protect from light and oxidation. Market Positioning High Efficiency– Significantly outperforms traditional retinol and retinyl palmitate. Safety– Non-irritating and su [NanoActive RETINAMIDE视黄酰胺] 化学特性 NanoActive RETINAMIDE视黄酰胺是视黄酰胺的衍生物，通过将视黄酸与聚乙二醇（PEG）共轭，形成聚乙氧基化视黄酸。该结构显著提升了其水溶性、稳定性及皮肤渗透性，同时降低了刺激性与降解风险。 功能与优势 2.1 抗衰老作用 促进胶原蛋白合成：显著增加皮肤胶原蛋白的生成，从而减少皱纹和细纹的出现。 减少弹性蛋白降解：通过抑制弹性蛋白的分解，提高皮肤弹性，令肌肤更紧致。 抗氧化：具备抗氧化能力，抵御自由基损伤，延缓皮肤老化。 2.2 皮肤渗透性 通过纳米包裹技术，NanoActive RETINAMIDE视黄酰胺可显著提高皮肤吸收率。研究表明，其皮肤渗透能力为传统视黄醇及视黄醇棕榈酸酯的数倍。 其亲水性使其能够轻松穿透皮肤屏障，深入真皮层，发挥抗衰老功效。 2.3 稳定性 酰胺键稳定性：通过酰胺缩合反应形成稳定酰胺键，避免像传统视黄酯（如HPR）那样在货架期内逐渐水解为禁用的视黄酸，使NanoActive RETINAMIDE视黄酰胺成为长期使用的更安全、更稳定替代品。 环境稳定性：在光照、氧气及高温条件下具有更高稳定性，解决传统视黄酰胺易降解问题。 配方稳定性：在O/W乳液中稳定性优于视黄醇及视黄醇棕榈酸酯，适用于多种化妆品剂型。 PEG 贡献：PEG的亲水性使成分更易溶于水并渗透皮肤，同时保护分子免受氧化和降解，支持日间使用。 2.4 安全性 多项毒理学测试表明，NanoActive RETINAMIDE视黄酰胺无刺激、无致敏，适合长期使用。 已通过过敏与皮肤刺激测试，温和不引起泛红或刺激。 与专利舒缓配方 PuriActives®FastCalmin结合，可有效预防传统视黄醇类成分常见的不良反应，进一步提升安全性和耐受性。 应用场景 3.1 核心抗衰老用途 抗皱精华：淡化皱纹与细纹 紧致面霜：提升弹性，改善松弛 美白产品：通过促进胶原合成，均匀肤色 防晒与修护：增强皮肤自我修复，减少光老化损伤 3.2 基于维甲酸临床功效的拓展用途 （以下用途均利用NanoActive RETINAMIDE视黄酰胺的高渗透、低刺激及光稳定性优势） 应用领域 作用机制 适配产品类型 痤疮（粉刺/炎性痘） 调节毛囊角化、减少皮脂分泌、抗炎抑菌 祛痘精华、控油乳液、局部点涂凝胶 毛周角化症（鸡皮肤） 促进角质代谢，疏通毛囊，平滑粗糙 身体乳、角质调理霜 银屑病（轻中度斑块型） 抑制表皮过度增殖，促进正常角化 舒缓修护霜、头皮乳液 扁平疣/HPV感染 诱导角质细胞凋亡，激活局部免疫 冷冻术后修复凝胶、低刺激角质剥脱笔 色素沉着（黄褐斑、痘印） 抑制黑色素传递、加速表皮更新 淡斑精华、美白面膜、术后修护精华 光老化/日光性角化病 修复紫外线引起的胶原断裂、减少癌前病变 抗氧化日霜、SPF复合修护喷雾 鱼鳞病及角化异常 纠正角化缺陷，缓解干燥脱屑 高保湿修护霜、儿童专用润肤乳 医美术后修复 促进再上皮化与胶原重塑，降低刺激 术后48小时可用屏障修复霜、微针/激光术后精华 使用建议 剂型建议：优先用于夜间产品，避免光照；若配方稳定且含防晒，可支持日间使用。 推荐浓度：一般为1–5%，可根据产品定位调整。 包装建议：采用不透明容器，避光保存。 市场定位 高效性：功效显著优于传统视黄醇 安全性：敏感肌友好，无刺激 创新性：纳米技术提升体验与效果，可切入功效护肤、医美修复、问题肌肤等高增长赛道 临床研究支持 多项临床研究表明，NanoActive RETINAMIDE视黄酰胺在促进胶原蛋白合成、减少皱纹、提升弹性等方面表现优异，且耐受性良好、刺激性低。 企业信息 PuriPharm Co. Ltd.，高科技生物医药企业，专注于功能性活性原料与纳米生物药物开发。以绿色化学、合成生物学、纳米包裹及植物提取为核心技术平台，产品广泛应用于医药、功能性化妆品及食品领域。 [NanoActive RETINAMIDE 视黄酰胺——新一代纳米包裹维生素A]

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NanoActive™ RETINAMIDE

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PuriPharm

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Actives, Humectants

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Anti-aging/Wrinkle Care, Formulation Stability

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NMPA

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1–5%

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