SYN®-UP

원료 설명

효능 Promotes healthy-looking skin for longer by inhibiting Plasmin activities and by interacting with the skin microbiome**, Makes the skin more resilient against stress attacks day- by- day **, Real, significant prevention of dry skin conditions**, Reduces redness and unpleasant skin sensations**, Significant promotion of great looking skin**, Helps to smooth and firm the skin*, *In vitro, **in vivo", High Plasmin and Bacteria disbalance play a central role in unhealthy-looking skin, Plasmin is an enzyme responsible for protein activation and degradation and is widely present in the epidermis of the skin. High Plasmin activities:, Affect the Cornified Envelope, , important for the protection and maintenance of the skin barrier., Activate MMP 9, Activate MMP 1 levels, leading to the, degradation of type I Collagen, so the skin has less structural support, 2, . When Collagen is compromised, skin loses elasticity & firmness., Disbalanced bacteria, :, S. aureus, affects skin barrier function via bacterial proteases, inflammation is triggered, and Plasmin is further activated leading to an even more vulnerable barrier, 1, .​, 1. Allergy Asthma Immunol Res. 2019 Sep;11(5): 593-603​, 2. Experimental Dermatology 2018;27:520–525., SYN-UP® unlock your skin's longevity, One biological target (Plasmin) to drive improvement across all skin layers., SYN-UP® promotes healthy-looking skin, by inhibiting Plasmin and Urokinase* activities and balancing key bacteria, S. Aureus, * and, S. Epidermidis, **.., SYN-UP® reduces skin sensitivity and redness, by modulation of MMP 9, CXCL5 and IL-8 activities*., SYN-UP® increases skin barrier functionality, by up-regulation of Transglutaminase 1 (TGase1)*., SYN-UP® helps to smooth and firm the skin, by preventing the degradation of type IV Collagen* and by stimulating type I Collagen*., *in vitro ​ **in vivo

Unlock your skin's longevity Our unique peptide SYN-UP® has excellent capacity to improve the barrier functionality, by interacting with the skin microbiome, combats skin dryness, sensitivity and redness, and helps to smooth and firm the skin. Beauty runs deep… our skin is a perfect ecosystem, multiple levels of cells and molecules all interconnected to build this great organ of the body. Over time external stressors such as UV irradiation, climate, pollution or chemicals can disbalance the skin. This process activates the production of Plasmin, triggering a series of skin damages and visible signs of aging. As a result skin becomes more fragile, prone to sensitization, loses its vitality and firmness, leaving the skin with an unhealthy appearance. SYN-UP® is the peptide solution for multiple skin benefits. It improves the barrier functionality, by interacting with the skin microbiome, combats skin dryness, sensitivity and redness, and helps to smooth and firm the skin. SYN-UP® is now allowed to be used in skincare formulations in the China market with its successful notification as a New Cosmetic Ingredient (NCI) in under the country’s new cosmetic legislation. Mode of Action SYN-UP® targets Plasmin SYN-UP® peptide is the key to unlock skin’s own true potential from within. Visualized with molecular modelling SYN-UP® peptide fits perfectly in the active site of Plasmin, like a key in a lock, with the objective of re-balancing Plasmin in the skin and reversing the negative impact. Product Features INCI name (active): Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate Sophisticated patented synthetic dipeptide derivative Benefits Promotes healthy-looking skin for longer by inhibiting Plasmin activities and by interacting with the skin microbiome** Makes the skin more resilient against stress attacks day- by- day ** Real, significant prevention of dry skin conditions** Reduces redness and unpleasant skin sensations** Significant promotion of great looking skin** Helps to smooth and firm the skin* *In vitro **in vivo" High Plasmin and Bacteria disbalance play a central role in unhealthy-looking skin Plasmin is an enzyme responsible for protein activation and degradation and is widely present in the epidermis of the skin. High Plasmin activities: Affect the Cornified Envelope , important for the protection and maintenance of the skin barrier. Activate MMP 9 leading to increased levels of inflammatory cytokines and red skin conditions. Increased levels of MMP 9, which are also elevated in sun-exposed skin, mediate degradation of type IV Collagen, a major component in the Dermal Epidermal Junction. Activate MMP 1 levels leading to the degradation of type I Collagen so the skin has less structural support 2 . When Collagen is compromised, skin loses elasticity & firmness. Disbalanced bacteria : S. aureus affects skin barrier function via bacterial proteases, inflammation is triggered, and Plasmin is further activated leading to an even more vulnerable barrier 1 .​ 1. Allergy Asthma Immunol Res. 2019 Sep;11(5): 593-603​ 2. Experimental Dermatology 2018;27:520–525. SYN-UP® unlock your skin's longevity One biological target (Plasmin) to drive improvement across all skin layers. SYN-UP® promotes healthy-looking skin by inhibiting Plasmin and Urokinase* activities and balancing key bacteria S. Aureus * and S. Epidermidis **.. SYN-UP® reduces skin sensitivity and redness by modulation of MMP 9, CXCL5 and IL-8 activities*. SYN-UP® increases skin barrier functionality by up-regulation of Transglutaminase 1 (TGase1)*. SYN-UP® helps to smooth and firm the skin by preventing the degradation of type IV Collagen* and by stimulating type I Collagen*. *in vitro ​ **in vivo

원료 정보

상품명

SYN®-UP

복합물상품명

미확인

공급사

1곳

제조사

DSM

종류

Actives

용도

Anti-aging/Wrinkle Care

인증·등록

NMPA

구성 성분 (1)

공급사 (1)

규격 및 사용 정보

INCI

Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate

CAS 번호

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EC 번호

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원산지

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성상

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용해성

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pH

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권장 사용량

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보관 조건

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사용 기한

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포장 단위

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기술 문서 (TDS·SDS·COA)

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