NanoActive™ DHM(리포좀)

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[NanoActive DHM] NanoActive DHM Epigenetic Youth Restorer & DNA Methylation Inhibitor 1. PRODUCT IDENTIFICATION Product Name: NanoActive DHM Trade Name: NanoActive DHM by PuriPharm INCI Name: Water, Glycerin, Caprylic/Capric Triglyceride, Ampelopsis Grossedentata Extract, Phospholipids, Tocopheryl Acetate. Botanical Source of Active: Ampelopsis grossedentata(Vine Tea) Active Content: 9.5% – 10.5% (Ampelopsis Grossedentata Extract) 2. PRODUCT DESCRIPTION NanoActive DHM represents a paradigm shift in epigenetic anti-aging. Developed by PuriPharm Co. Ltd., it is the industry's first cosmetically viable DNA methylation inhibitor. Utilizing advanced nanoliposomal technology, highly purified Dihydromyricetin (DHM) is encapsulated in a biomimetic phospholipid bilayer. This sophisticated delivery system overcomes the inherent instability and poor skin penetration of DHM, allowing for targeted delivery to the deep epidermis and dermis, fundamentally reversing cellular aging at the genetic transcription level. 3. MECHANISM OF ACTION Environmental stressors (UV, pollution) and intrinsic aging lead to hypermethylation of DNA, which functionally "silences" essential youth and structural genes. Epigenetic Reversal: NanoActive DHM acts as a potent DNA methylation inhibitor, effectively removing age-induced methyl tags. Gene Reactivation: By modulating over 10,000 methylation sites, it reactivates silenced genes associated with the Extracellular Matrix (ECM), signal transduction, and autophagy. Targeted Delivery: The 50-150 nm liposomal spheres ensure enhanced transdermal absorption and a sustained-release profile, maximizing biological availability and minimizing potential irritation. 4. TECHNICAL SPECIFICATIONS 5. EFFICACY & CLINICAL DATA SUMMARY Transcriptomic Upregulation: Significantly upregulates key structural genes including COL6A1 (Collagen Type VI), ITGB6, ITGA5, and VCL, restoring cellular anchorage and tissue firmness. 3D Skin Equivalent Model: In a 6-week in vitrostudy utilizing 20µM DHM on mature 3D skin models, NanoActive DHM effectively reversed epidermal thinning. Epidermal thickness increased from 30µm (untreated mature control) to ~50µm, closely mirroring the baseline of young skin models (60µm). Statistical significance achieved (p = 0.00064). 6. FORMULATION GUIDELINES NanoActive DHM is designed for ease of use in premium cosmetic formulations. Recommended Usage Level: 1.0% – 5.0% Incorporation Phase: Add to the aqueous phase or during the cooling phase (below 45°C) for emulsions to maintain liposomal integrity. pH Compatibility: Stable within a final formulation pH range of 4.5 – 7.5. Incompatibilities: Avoid high concentrations of strong ionic surfactants or extreme ethanol levels (>20%) which may disrupt the lipid bilayer. Processability: Do not subject to intense, prolonged shear force (homogenization > 3000 rpm for extended periods) after incorporation. 7. TARGET APPLICATIONS Premium Anti-Aging Skincare: Serums, night creams, and eye treatments targeting chronological aging and photoaging. Medical Aesthetics Post-Care: Restorative formulations designed to prolong the effects of clinical treatments by maintaining epigenetic cellular health. Preventative Aging: Solutions targeting millennials/Gen-Z exposed to urban pollution, stress, and lifestyle-induced epigenetic damage. 8. STORAGE & SHELF LIFE Storage Conditions: Store in a cool, dry place away from direct sunlight. Recommended storage temperature: 4°C – 25°C. Do not freeze. Keep containers tightly sealed when not in use. Shelf Life: 24 months from the date of manufacture under optimal storage conditions. Disclaimer: The information provided herein is based on our current knowledge and rigorous scientific testing. It is intended for informational purposes for cosmetic professionals and formulators. It is the responsibility of the formulator to ensure the stability, safety, and regulatory compliance of the final consumer product. PuriPharm Co. Ltd.Pioneering Epigenetic Skincare SolutionsWebsite: www.puriactives.com | Email: service@puripharm.com [NanoActive DHM] Scientific Breakthrough: Epigenetic Anti-AgingDeveloped byPuriPharmCo. Ltd. 1. Epigenetics and Skin Aging What is Epigenetics? Epigenetics is the science studying how lifestyle and environmental factors influence gene expression. This process occurs without changing the underlying DNA sequence. Instead, it alters gene activity by turning genes "on" or "off" based on external stimuli. It provides a profound new target for anti-aging interventions by addressing the root causes of cellular decline. The Identical Twins Study Primary Drivers of Skin Aging The Process of DNA Methylation Lifestyle and environmental factors influence gene expression primarily through DNA methylation. Methyl groups (epigenetic factors) attach to the DNA molecule. These methylation marks can activate or, more commonly in aging, improperly repress or "silence" specific genes. This makes the DNA inaccessible to the machinery that keeps cells youthful and functional. Hypermethylation and Aging 2. The DHM Breakthrough Introducing Dihydromyricetin: The world's first cosmetic DNA methylation inhibitor. A Global Innovation Dihydromyricetin (DHM)： NanoActive DHM features Dihydromyricetin, globally recognized as the first cosmetic ingredient scientifically proven to inhibit DNA methylation. This represents a paradigm shift, leading a completely new direction in epigenetic anti-aging interventions. Mechanism of Action Inhibit Methylation: DHM acts directly at the genetic level to regulate and inhibit the excessive DNA methylation patterns that accumulate over time. Reactivate Youth Genes: By removing these inhibitory methyl tags, DHM successfully reactivates silenced youth genes. Restore Vitality: This fundamentally delays cellular aging by returning skin cells to their peak functional state, rather than just treating surface symptoms. Natural Plant Source NanoActive DHM is extracted exclusively from Ampelopsis Grossedentata, commonly known as Vine Tea. It belongs to the Vitaceae family, Ampelopsis genus. This specific plant is exceptionally rich in naturally occurring Dihydromyricetin. It provides a clean, sustainable, and highly potent botanical source for epigenetic anti-aging formulations. Cultivation & Extraction 3. Advanced Nanoliposome Technology Nanoliposome Principles Definition: Nanoliposomes are microscopic vesicles composed of phospholipid bilayers that perfectly mimic the human cell membrane structure. Average Size: Ranging from 10 to 50 nm, they are perfectly sized to penetrate the skin barrier effectively. Technology Advantages The Dual Breakthrough 4. Clinical Efficacy and Validation DNA Methylation Impact Reversing the Clock It successfully induced a young epidermal DNA methylation pattern, restoring youthful epigenetic characteristics. Epidermal Structure Improvement Reactivation of Youth Genes 5. Market Application & Value Competitive Advantage Target Market & Applications [NanoActive DHM] 1. 表观遗传学与肌肤衰老 表观遗传学是一门前沿科学，研究生活方式和环境因素如何影响基因的表达。 这一调控过程不会改变人类底层的DNA序列。 相反，它通过响应外部刺激，将特定基因动态地“开启”或“关闭”。 它从细胞衰老的根源入手，为高端抗衰老干预提供了极具科学深度的全新靶点。 同卵双胞胎的科研启示 驱动肌肤衰老的核心外源因素 DNA甲基化调控机制 生活方式和环境因素主要通过DNA甲基化 (DNA Methylation) 来干预基因表达。 甲基基团（表观遗传因子）如同标签一样附着在DNA分子上。 在衰老过程中，这些过度积累的甲基化标记往往会错误地“沉默”特定的关键青春基因。 这导致维持细胞年轻、促进胶原生成的转录机制受到阻断，皮肤开始呈现结构性衰老。 DNA高甲基化与细胞衰老 2. DHM的突破性发现 行业级原料创新突破——二氢杨梅素 (DHM) NanoActive DHM 的核心赋活成分为二氢杨梅素，这是目前全球化妆品原料界公认的、被科学证实能有效抑制DNA甲基化的活性物。它代表了一次重大的范式转移，跨越了表层修饰，直接引领了基因级表观遗传抗衰老的全新方向。 核心作用机理 靶向抑制甲基化： DHM直接介入基因水平调控，有效抑制随时间和环境压力不断积累的异常DNA高甲基化模式。 逆转重启青春基因： 通过干预并移除这些致衰性的甲基“封印”，DHM成功重新激活被沉默的青春与修复基因。 深度恢复细胞生命力： 从根本上逆转细胞衰老轨迹，使表皮及真皮细胞恢复至巅峰的功能与代谢状态，远超传统抗老原料的表层维稳效果。 珍稀天然植物溯源 NanoActive DHM 独家高纯度提取自中国特有植物 显齿蛇葡萄 (Ampelopsis Grossedentata)，俗称“藤茶”。 在植物分类学上，它属于葡萄科 (Vitaceae)，蛇葡萄属。 经过科研筛选，该特定植物被证实富含极高浓度的天然二氢杨梅素类黄酮。 经过科研筛选，该特定植物被证实富含极高浓度的天然二氢杨梅素类黄酮。 道地栽培与尖端精提 3. 前沿纳米脂质体技术 脂质体载体原理 仿生结构： 纳米脂质体是由磷脂双分子层构成的微观囊泡体系，其结构完美模拟并高度亲和人体细胞膜。 粒径优势： 平均粒径严格控制在 10 至 50 nm 之间，这一纳米级尺寸使其能够轻松跨越角质层物理屏障。 高效包载： 具备极高的药物包封率，能够将DHM稳固包裹于囊泡内，彻底解决传统黄酮类物质配方难溶的痛点。 配方与应用技术优势 产品双效协同突破 4. 临床功效与科学验证 对DNA甲基化的宏观影响——逆转分子时钟 在严谨的实验条件下（使用 20µM DHM 处理 3D 皮肤等效模型 6 周），检测发现 DHM 治疗显著调控了超过 10,000 个DNA甲基化位点。它以惊人的效率清除了老化的表观遗传印记，成功诱导衰老组织恢复年轻表皮特有的健康模式。 3D皮肤等效模型验证 转录组学：重启关键青春基因 5. 市场应用与核心价值 核心竞争优势对比 目标市场定位与应用 Tagged 保湿, 化妆品.

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NanoActive™ DHM(리포좀)

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PuriPharm

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Actives

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Antioxidant, Barrier Protection

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INCI

Water, Glycerin, Caprylic/Capric Triglyceride, Ampelopsis Grossedentata Extract, Phospholipids, Tocopheryl Acetate

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pH

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권장 사용량

1.0%–5.0%

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Shelf Life

24 months from the date of manufacture under optimal storage conditions.