NanoActive™ Sulfur (유황리포좀)

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[NanoActive Sulfur PRODUCT DATA SHEET] Advanced Nano-Encapsulated Bio-Derived Sulfur for Multi-Targeted Skin Solutions Company: PuriPharm Co. Ltd. Website: www.PuriActives.com Contact: Service@puripharm.com | Tel: 13167223168 1. PRODUCT OVERVIEW Sulfur is a naturally occurring nonmetal with a long-standing dermatological history of effectively treating various skin disorders. However, traditional sulfur applications are severely limited by poor water solubility, large particle sizes (2–5 μm), low bioavailability, and formulation challenges. NanoActive Sulfur, developed by PuriPharm Co. Ltd., is a cutting-edge active ingredient that utilizes a proprietary Nano-Delivery System (NDS). By stably encapsulating highly active bio-derived sulfur into sub-30 nm lipid-based nanocarriers, it completely resolves traditional solubility and aesthetic issues. The result is a highly bioavailable, transparent, and universally compatible active that regulates sebum, reduces inflammation, and offers potent antibacterial properties for acne and scalp care. 2. COMPOSITION & INCI INFORMATION NanoActive Sulfur is formulated using a specialized biomimetic lipid matrix designed for optimal trans-epidermal delivery. It is strictly free from added preservatives and antioxidants. Composition Range Table: 3. TECHNICAL SPECIFICATIONS 4. TECHNOLOGY HIGHLIGHTS: THE NDS ADVANTAGE Ultra-Fine Particle Size (< 30 nm): Significantly increases the specific surface area and interaction with keratinocytes, ensuring superior skin penetration and biological activity compared to traditional 2-5 μm sulfur. Exceptional Formulation Flexibility: The unique hydrophilic-lipophilic structural modification allows NanoActive Sulfur to be seamlessly incorporated into lotions, creams, clear gels, and water-based formulas without precipitation. Aesthetic Superiority: Unlike traditional sulfur, which is chalky and difficult to suspend, NanoActive Sulfur maintains optical clarity (forming a transparent solution at typical usage levels), leaving no residue and enabling elegant cosmetic formulations. High Stability & Bioavailability: The robust phospholipid-based nanocarrier prevents aggregation, protects the active payload, and ensures targeted delivery to the sebaceous glands and follicles. 5. KEY COSMETIC BENEFITS & MECHANISM OF ACTION A. Comprehensive Sebum Regulation & Keratolysis Excessive sebum accumulation leads to enlarged pores, follicular blockage, and inflammation. NanoActive Sulfur effectively removes surface lipids, softens the epidermis, and dissolves keratin plugs. ●Mechanism:At low concentrations, sulfur exerts a keratoplastic effect, promoting normal keratinization. At higher concentrations, it becomes keratolytic, reacting with cysteine to form cystine and hydrogen sulfide (), which safely disrupts excess keratin and clears clogged pores. B. Targeted Antibacterial & Antifungal Action NanoActive Sulfur acts as a potent purifying agent and helps rebalance the skin microbiome. ●Mechanism: Skin bacteria and keratinocytes convert sulfur into pentathionic acid (), a compound highly toxic to fungi and pathogenic bacteria. The keratolytic action further helps detach microorganisms from the stratum corneum. ●Microbiological Efficacy (In Vitro): ○P. aeruginosa: MIC = 1.95 μg/mL | MBC = 1000 μg/mL ○S. aureus: MIC = 125 μg/mL ○E. coli: MIC = 500 μg/mL C. Powerful Anti-Inflammatory & Soothing Properties Severe oxidative stress depletes intracellular Glutathione (GSH), triggering inflammatory cascades. ●Mechanism:NanoActive Sulfur supports cellular antioxidant defenses by promoting GSH synthesis. ●Efficacy:Exerts a strong, dose-dependent reduction in the expression of key pro-inflammatory cytokines. Clinical evaluations (ELISA) show that concentrations between 0.1% and 0.4% significantly downregulate the protein expression ofIL-1β,IL-6, and TNF-α. D. Inin-vivoassessments, formulations containing NanoActive Sulfur demonstrated visible improvement in acne-prone skin profiles. A 60-day application of 0.2% active showed a significant reduction in inflammatory lesions and post-acne erythema, making it an ideal candidate for long-term acne management. 6. RECOMMENDED APPLICATIONS NanoActive Sulfur is highly versatile and is recommended for the following cosmetic product categories: Acne & Blemish Control: Spot treatments, anti-acne serums, and purifying toners. Sebum Control & Pore Refining: Mattifying lotions, oil-control powders, and deep-cleansing masks. Brightening & Spot-Fading: Post-inflammatory hyperpigmentation (PIH) correctors. Soothing & Repair: Products targeting sensitized, inflamed, or compromised skin barriers. 7. FORMULATION GUIDANCE Suggested Use Level: 0.1% – 5.0% (Depending on target efficacy: low doses for daily maintenance/anti-inflammation; higher doses for targeted spot treatments). Solubility: Amphiphilic nature allows it to be easily added to either the aqueous phase or the final emulsion at room temperature or gently heated conditions. Compatibility: Compatible with a wide range of cosmetic ingredients, including traditional water-based and oil-based systems. Does not cause phase separation. 8. STORAGE, HANDLING & PACKAGING Storage: Store in the original, unopened container at 4°C to 25°C. Protect from direct sunlight and maintain in a dry environment. Shelf Life: 12 months under specified storage conditions. Packaging: Supplied in standard industrial plastic containers. Disclaimer: The information contained in this document is provided in good faith and is based on our current knowledge and internal testing. Formulators are responsible for ensuring the final cosmetic product's stability, safety, and regulatory compliance in their respective target markets. PuriPharm Co. Ltd. | Advanced Active Ingredients [NanoActive Sulfur] Introduction Its activity depends on the interaction between sulfur particles and keratinocytes: the smaller the particles, the larger the contact area and the better the efficacy. Bio-derived sulfur formed by the bacterial oxidation of sulfides into elemental sulfur shows better spreadability on the skin and higher activity. Sebum Regulation Excessive sebum secretion accumulates in follicles, enlarges pores, causes follicular blockage, and may even trigger inflammation. NanoActive Sulfur effectively removes excess surface oil and helps soften the epidermis. It can also dissolve keratin and relieve skin imbalance caused by overactive oil secretion. Keratolytic Effect Cystine is a major component of the stratum corneum. At low concentrations, sulfur promotes normal keratinization through its keratoplastic activity. At high concentrations, the same reaction produces a keratolytic effect because hydrogen sulfide disrupts keratin, and sufficient accumulation can dissolve the stratum corneum. Therefore, NanoActive Sulfur is recommended for cosmetic formulations designed to regulate sebum secretion. Antibacterial Action The antibacterial action of sulfur depends on its conversion into pentathionic acid (H₂S₅O₆), a compound toxic to fungi. Hydrogen sulfide may also contribute to this activity. Through the action of skin bacteria and keratin-forming cells, sulfur can be converted into pentathionic acid. In addition, sulfur's keratolytic activity may help separate fungi from the stratum corneum. Therefore, NanoActive Sulfur is recommended for cosmetic formulations with purifying and preservative functions. Pentathionic Acid Activity Anti-inflammatory Action Glutathione (GSH) is the most important cellular antioxidant. It exists in the reduced thiol form (GSH) and the oxidized disulfide form (GSSG), and undergoes thiol-disulfide exchange catalyzed by thiol transferases. Severe oxidative stress depletes intracellular GSH. NanoActive Sulfur can promote GSH synthesis while reducing pro-inflammatory cytokines such as IL-1, IL-6, and TNF-α, delivering a strong anti-inflammatory effect. Inflammatory Factor Reduction Inflammatory Factor Reduction The protein expression levels of TNF-α, IL-1β, and IL-6 were measured by ELISA. Compared with the control group, NanoActive Sulfur reduced the expression of TNF-α, IL-1β, and IL-6 in a dose-dependent manner. 5% NanoActive Sulfur 2 months Visible improvement in acne appearance after continuous use. Challenges in Sulfur Applications Advantages of NanoActive Sulfur NanoActive Sulfur has a unique chemical structure (linear and hydrophilic), making it easier to formulate, easier to combine with other ingredients, and easier to absorb. Nano-delivery System NanoActive Sulfur developed with a nano-delivery system (NDS) has a particle size below 30 nm. It completely solves sulfur solubility issues by stably encapsulating sulfur inside nano-carriers, greatly improving absorption efficiency and bioavailability. NanoActive Sulfur Applications Market Cases [NanoActive Sulfur] Nanoactive Sulphur is a new type of sulphur nanoliposome preparation (NanoLiposomal Sulphur). Product Name: Nano Liposomal Sulfur; Nanoactive Sulfur; BioaActive Sulfur; Soluble Sulfur CAS: 7704-34-9 Description ： It is a yellow non-metallic element widely distributed in the earth's crust. The function of sulphur depends on its direct interaction with the skin. The smaller the particles are, the larger the effective area of ​​interaction between sulfur and the skin is, and the greater the efficacy is. Nanobiosulfuris a sebum regulating agent that has triple effects on problem skin, namely antibacterial, anti-inflammatory and sebum regulating. Water-soluble and non-irritating to the skin, in cosmetics, it can regulate the secretion function of sebaceous glands, facilitate skin whitening. It is also effective in anti-bacteria, reducing the appearance of whelk, acne and dandruff. SulfurSarcoptic Mitecan kill bacteria and fungus, strip the skin of oil, soften the epidermis, dissolve the keratin Sulfurby forming pentathionic acidSecretionafter interactingHydrogen sulfidewith skin and tissue. Lipoic acid nanoactive material with a particle size of less than 30 nm developed by Nano-transport system (NDS) has completely solved sulfur's solubility problem, allowing it to be stably encapsulated in a nanocarrier, which can greatly increase its absorption efficiency and bioavailability. Lipoic acid’s structure Sulphur is a yellow colored non-metal element, widely distributed throughout the planet. Different sulphur-based topical preparations have been developed through the years. Sublimed sulphur is prepared by changing sulphur from solid to gas (sublimation). The resulting gas is subsequently condensed into fine yellow powder, which can be used in different ways. The physical properties of sublimed sulphur differ from those of precipitated sulphur. Sublimed sulphur, Washed sulphur, is made of large particles with mild therapeutic efficacy; it is yellow, nonsoluble in water or alcohol, slightly soluble in olive oil (10%) and tastes slightly acidic. Washed sulphur is sublimed sulphur, treated With diluted ammoniac first and boiling water afterwards. Precipitated sulphur, also called magistery of sulphur or milk of sulphur, is made of small particles with high therapeutic efficacy; it is whitish-yellow, non soluble in water, slightly soluble in alcohol, soluble in 1:100 olive oil and insipid. Nanoactive sulphur consists of minute particles, smaller than those of precipitated sulphur (1 to 100 nm), which can be suspended in a colloidal solution. So far, this form is considered the most active one. Currently, the so-called biosulphur is most Frequent used, because of its better diffusion and higher activity on the skin. TRADITIONAL USES Sulphur has been used for medicinal purposes since the times of Hippocrates. Commercially, this product is important to produce sulphuric acid, abundantly used in the chemical industry and others. COSMETIC PROPERTIES Keratolytic properties The action of sulphur depends on its direct interaction with the skin. The smallest particle sizes have the largest interaction area and therefore, they are most efficient. For many years, sulphur has been considered a specific remedy for seborrhea, used as octahedral sulphur solution in The therapeutic effects of sulphur on acne-prone skin or skin with excessive sebum secretion could result from its keratolytic action. The mechanism underlying such effect is not known; it probably depends on the interaction of sulphur with the cysteine Into keratinocytes Cystine is a major constituent of the horny layer. This reaction promotes normal keratinization, due to the keratoplastic effect of sulphur, applied at low concentrations.Applied at high concentrations, the same reaction causes keratolytic effects, because sulphur hydrogen breaks keratin.It is possible That applications of high sulphur concentrations on the skin result in sulphur hydrogen enough enough to dissolve the horny layer Therefore, nanoactive sulphur fluid is recommended to formulate cosmetic products with regulatory activity on sebum secretions. Antifungal action Sulphur antifungal action depends on the conversion of sulphur into pentathionic acid, a Compound toxic to fungi. Sulphur hydrogen formation could also be involved in this action. Applied on the skin, sulphur turns into pentathionic acid due to the action of skin bacteria and Keratinolytic. of keratolytic action of sulphur could cause the fungi to detach from the horny layer Therefore, nanoacive sulphur fluid is recommended to formulate cosmetic products with purifying and antiseptic action COSMETIC APPLICATIONS Features NanoActive Sulfur uses FDA GRAS grade materials for high safety NanoActive Sulfur has good heat, pH and shear stability and is easy to use. NanoActive Sulfur greatly improves the stability and bioavailability of ALA NanoActive Sulfur improves the stability and absorption of other actives in the product NanoActive Sulfur is 100% water soluble and 100% oil soluble (amphiphilic) for a wide range of applications Product use:Add at room temperature,heat it to above 40°C to speed up its dissolution. Recommended dosage: 1-3%. Better effect with products containing lipoic acid. Product storage: Keep below 25°C and away from light. [纳米生物硫磺（NanoActive Sulfur）] 纳米生物硫磺是一种皮脂调节剂，对于问题皮肤具有三重功效，即抗菌、抗炎和皮脂调节功能。利用纳米传输系统（NDS）开发的粒径小于30nm的硫辛酸纳米活性物，完全解决了硫磺溶解性问题，大幅增加吸收效率和生物利用度。 硫磺是一种历史悠久的治疗多种皮肤病的有效药物硫磺是一种黄色非金属元素,广泛分布于地壳。硫磺的作用取决于与皮肤的直接相互作用。颗粒愈小，硫磺与皮肤互相作用的有效面积愈大，功效也愈大。纳米生物硫磺是一种皮脂调节剂，对于问题皮肤具有三重功效，即抗菌、抗炎和皮脂调节功能。水溶性，对皮肤无刺激性，在化妆品中可调理皮脂腺的分泌，促进美白功能，更有抗菌功能，另对青春痘、痤疮及头皮屑也有很好的疗效。硫磺对疥虫、细菌、真菌有杀灭作用并能除去油脂及软化表皮，溶解角质，其作用机制是硫磺与皮肤及组织分泌物接触后，生成硫化氢和连五硫酸等的结果。 利用纳米传输系统（NDS）开发的粒径小于30nm的硫辛酸纳米活性物，完全解决了硫磺溶解性问题，让硫磺稳定地包裹于纳米载体之中，能大幅增加吸收效率和生物利用度。 硫磺结构 硫磺是一种黄色的非金属元素，广泛分布在整个星球上。多年来已开发出不同的硫磺外用制剂。通过将硫从固体变为气体（升华）来制备升华硫。随后将所得气体冷凝成细黄色粉末，其可以不同方式使用。升华硫的物理性质不同于沉淀硫。升华的硫磺，洗过的硫磺或硫磺花，由具有温和治疗功效的大颗粒组成，黄色、不溶于水或酒精，微溶于橄榄油（10％），味道略带酸性。 纳米活性硫由微小颗粒（1至100nm）组成，小于沉淀硫，其可以悬浮在胶体溶液中，到目前为止被认为是活性最佳的形式。目前，纳米生物硫是最常用的，因为它具有更好的扩散和更高的皮肤活性。 自希波克拉底时代以来，硫磺一直被用于药用目的。硫的作用取决于它与皮肤的直接相互作用。最小的粒径具有最大的相互作用区域，因此它们是最有效的。多年来，硫磺已被认为是皮脂溢的特定药物。硫磺对痤疮易发皮肤或皮脂分泌过多的皮肤的治疗效果可能是由于其角质溶解作用。这种影响背后的机制尚不清楚;它可能取决于硫与半胱氨酸相互作用进入角质形成细胞。 胱氨酸是角质层的主要成分。由于低浓度的硫磺的角质效应，这种反应促进了正常的角质化。在高浓度下应用相同的反应会引起角质溶解作用，因为硫氢酸会破坏角蛋白。高硫浓度的应用可能会对皮肤产生影响。在硫氢酸的积累足以溶解角质层。因此，推荐使用纳米活性硫液来配制对皮脂分泌具有调节活性的化妆品。 硫磺的抗真菌作用取决于硫转化为对真菌有毒的化合物–泛酸。硫氢酸形成也可能参与这一作用。由于皮肤细菌和皮肤角质形成细胞的作用，硫磺应用于皮肤可以转化成泛酸。此外，硫磺的角质溶解作用可能导致真菌从角质层脱离。因此，推荐纳米硫磺液配制具有净化和防腐作用的化妆品。 产品特点 NanoActive Sulfur采用FDA GRAS级原料，安全性高 NanoActive Sulfur对热、pH和剪切稳定性好，使用方便 NanoActive Sulfur大大提高了硫磺的稳定性和生物利用度 NanoActive Sulfur能提高产品中其他活性物的稳定性并促进吸收 NanoActive Sulfur可100% 水，适用范围广 产品使用：低温阶段加入，加热至40℃以上可以加快溶解速度，推荐用量:1-3%。与纳肤清、纳米视黄醛等产品配合使用效果更好。 产品储存：25℃以下避光保存。 关于纳米生物硫磺（NanoActive Sulfur） 中文名称：纳米生物硫磺 Product Name：NanoActive Sulfur

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NanoActive™ Sulfur (유황리포좀)

복합물상품명

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공급사

1곳

제조사

PuriPharm

종류

Actives

용도

Whitening/Brightening, Sebum Control, Acne/Blemish Control, Anti-aging/Wrinkle Care

인증·등록

NMPA

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공급사 (1)

규격 및 사용 정보

INCI

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CAS 번호

7704-34-9

EC 번호

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원산지

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성상

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용해성

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pH

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권장 사용량

0.1%–5.0%

보관 조건

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사용 기한

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포장 단위

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기술 문서 (TDS·SDS·COA)

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안전성 자료

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Storage

Store in the original, unopened container at 4°C to 25°C. Protect from direct sunlight and maintain in a dry environment.

Shelf Life

12 months under specified storage conditions.

Solubility

Amphiphilic nature allows it to be easily added to either the aqueous phase or the final emulsion at room temperature or gently heated conditions.