NanoActive™ BAICALIN (리포좀)

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[NanoActive® BAICALIN: The Intelligent "Telomerase" Activator for Cellular Youth] Unleashing Baicalin's Cellular Anti-Aging Potential through Advanced Nano-Targeted Delivery 1. Discovering Nature's Time Code: Baicalin & The Delivery Bottleneck Scutellaria baicalensis Georgi has long been revered as a "Golden Herb" in traditional Eastern medicine. Its core polyphenolic flavonoid active—Baicalin—has been extensively validated by top-tier SCI journals (e.g., Journal of Investigative Dermatology, Free Radical Biology and Medicine) for its outstanding pharmacological properties, including ROS scavenging, MMPs inhibition, and broad-spectrum UV protection. However, in modern dermatology and premium cosmetic applications, unmodified Baicalin faces a notoriously difficult translational gap: stellarin vitrodata, but mediocrein vivoefficacy. This is driven by three critical challenges: High Crystallinity & Poor Solubility: Highly prone to crystallization and precipitation in cosmetic emulsions or serums, making it impossible to maintain at high free-state concentrations. Extreme Physicochemical Instability: Containing multiple oxidation-prone phenolic hydroxyl groups, it easily browns and develops off-odors when exposed to light, heat, or mildly alkaline formulations. Extremely Low Bioavailability: Its large molecular polarity means it is heavily blocked by the dense "brick-and-mortar" structure of the Stratum Corneum, failing to penetrate into the dermis to exert gene-level targeted effects. PuriPharm: The NanoActive® Targeted Intelligent Delivery Solution Fusing biomimetic medicine with nanofluidic dynamics, PuriPharm utilizes its proprietary NanoActive® encapsulation technology. We have constructed Multilamellar Vesicles that highly mimic the structure of human cell membranes, precisely and stably embedding high-purity Baicalin within an amphiphilic nano-bilayer structure. This breakthrough technology completely dismantles Baicalin's physical barriers, achieving a systemic quadruple leap: High Solubility, Supreme Stability, Targeted Deep Penetration, and Prolonged Sustained Release. 2. Core Mechanism of Action (MoA): Targeting the Root of Cellular Senescence Leveraging the highly efficient transmembrane fusion capabilities of the NanoActive® carrier, Baicalin can reach efficacious therapeutic concentrations inside living cells, exerting critical regulatory roles across three cutting-edge anti-aging pathways: 2.1 Targeted Telomerase Activation, Guarding the DNA Terminal Lifeline Nobel Prize-winning research indicates that replicative cellular senescence is dictated by the "biological clocks" at the ends of chromosomes—Telomeres. UV irradiation and chronic oxidative stress dramatically accelerate telomere shortening, leading to irreversible cellular senescence. Upregulation of TERT Genes: NanoActive® BAICALIN penetrates deep into the nucleus to specifically activate or maintain the expression levels of Telomerase Reverse Transcriptase (TERT). Rescuing G1 Phase Arrest: It significantly downregulates core senescence switch genes p53 and p16INK4a (induced by DNA damage), enabling dormant senescent cells to regain their capacity for division and self-renewal, effectively turning back the clock at the genetic level. 2.2 Reversing SASP (Senescence-Associated Secretory Phenotype) — Cellular "Senomorphics" In modern anti-aging medicine, clearing or modifying the toxic factors secreted by senescent cells (SASP, e.g., IL-6, IL-8, MMPs) is the most sought-after strategy. NanoActive® BAICALIN demonstrates potent "Senomorphic" activity. It strongly inhibits the NF-κB inflammatory signaling pathway, severing the contagious cascade of SASP that destroys the surrounding healthy Extracellular Matrix (ECM), thereby protecting the Type I and Type III collagen networks. 2.3 Awakening the Nrf2/ARE Antioxidant Master Switch Transcending the limitations of traditional antioxidants (like Vitamin C and E) which consume themselves in a 1:1 ratio with free radicals, NanoActive® BAICALIN acts as an "ignition key" for the cell's endogenous defense mechanisms. By dissociating the Keap1-Nrf2 complex, it promotes Nrf2 nuclear translocation and binding to the ARE sequence, exponentially amplifying the expression of endogenous antioxidant enzymes (SOD, CAT, GSH-Px). 3. Outstanding Scientific Efficacy: Defining Anti-Aging Limits with Data 3.1 Nano-Targeted Delivery & Kinetics Experiment A: HaCaT Cellular Internalization Assessed using fluorescent probes (Coumarin-6) combined with flow cytometry and confocal microscopy. ●Results: After a 2-hour incubation, the absolute intracellular fluorescence intensity of the NanoActive® group was 4.2 times higher than that of the unencapsulated free Baicalin group. The biomimetic liposomes seamlessly fused via endocytosis, achieving highly efficient "targeted airdrops." Experiment B: Franz Diffusion Cell & Higuchi Release Model ●Penetration: The cumulative amount of Baicalin penetrating the porcine ear epidermis into the receptor fluid over 24 hours was 8.5 times greater for NanoActive® BAICALIN compared to standard Baicalin raw materials. ●Release Profile: The release curve perfectly aligns with the Higuchi Diffusion Equation (R² > 0.98), exhibiting characteristic matrix-type sustained release. It delivers a steady release over 24 hours, avoiding the "peak and valley" effect of drug concentration to ensure long-lasting, gentle, and effective results. 3.2 In Vitro & 3D Ex Vivo Skin Models Experiment C: Fibroblast Telomerase Activity Protection (TRAP Assay) Human primary fibroblasts were exposed to a UVA photo-damage model. ●Results: UVA reduced fibroblast telomerase activity to 31.2% of the normal group. Experiment D: 3D Full-Thickness Skin Model Remodeling Continuous topical application of the test substance on a reconstructed 3D skin model for 7 days. ●Results: H&E staining and immunofluorescence of tissue sections showed t [NanoActive® BAICALIN] A New Era in Telomerase-Targeted Anti-Aging: Ultimate Repair at the Cellular Core PURIPHARM: PIONEERS IN DELIVERY INNOVATION Leading the "Transdermal Delivery" Revolution PuriPharm is dedicated to the efficient delivery of biological active ingredients. The NanoActive® platform, driven by our proprietary NDS (Nano Delivery System) technology, overcomes the traditional limitations of active compounds regarding stability, solubility, and permeability. Focus on nano-encapsulation of bioactives. Pharmaceutical-grade R&D and manufacturing standards. Empowering premium global cosmetic brands. BAICALIN: NATURE'S "LONGEVITY FACTOR" Modern Science from Traditional Medicine Extracted from the roots of Scutellaria baicalensis, Baicalin is widely recognized in dermatology as a highly potent, multi-functional active ingredient. Extensive SCI research confirms its superior performance in delaying cellular senescence, neutralizing free radicals, and repairing UV damage. Key Profile: A high-purity flavonoid compound and a natural telomerase activator. TRADITIONAL CHALLENGES: FORMULATION BOTTLENECKS THE NANOACTIVE® SOLUTION Driven by Molecular Motor Technology NanoActive® BAICALIN utilizes ATP synthase molecular motor technology to encapsulate active molecules within biological microcapsules that highly simulate cellular membrane structures. Particle Size: 10-100nm, increasing transdermal delivery by 500%. Stability: Enhances anti-oxidative degradation capacity by more than 10 times. Solubility: 100% highly water-soluble for crystal-clear formulations. Core Mechanism: Molecular Targeted Repair TELOMERASE: THE "BIOLOGICAL CLOCK" Breaking the Hayflick Limit Telomeres are protective caps located at the ends of chromosomes that shorten with each cell division. Once telomeres are depleted, the cell enters a state of irreversible "Senescence". Telomerase is the only crucial enzyme capable of replenishing telomere length and resetting cellular lifespan. Baicalin is proven to be one of the very few natural small molecules capable of effectively activating this enzyme. CORE MECHANISM: ACTIVATING HTERT EXPRESSION DEFENDING AGAINST PHOTOAGING: UVA/UVB PROTECTION MOLECULAR TARGETS: REGULATING P53/P16 SIGNALING IN VITRO: SIGNIFICANT ROS SCAVENGING IN VITRO: PROMOTING FIBROBLAST PROLIFERATION IN VITRO: DNA DAMAGE REPAIR (Γ-H2AX) Clinical Research: Efficacy Validation CLINICAL: MULTI-DIMENSIONAL WRINKLE REDUCTION CLINICAL: ENHANCING ELASTICITY & FIRMNESS CLINICAL: IMPROVING TEXTURE & REFINEMENT COMPARISON: NANOACTIVE® VS TRADITIONAL FORMULATION GUIDELINES: STABILITY & COMPATIBILITY SAFETY & COMPLIANCE: RIGOROUS STANDARDS Redefining High-End Anti-Aging Actives NanoActive® BAICALIN is more than just an antioxidant; it is a molecular bridge across the Hayflick limit. Through precise targeting of telomerase, we enable skin cells to recapture the metabolic vitality of their youth. [NanoActive® BAICALIN 纳米包裹黄芩苷: 赋能细胞青春的“端粒酶”智能激活剂] 通过前沿纳米靶向递送技术，释放黄芩苷的细胞级抗衰潜能 1. 发现自然界的时间密码：黄芩苷 (Baicalin) 与递送瓶颈 黄芩（Scutellaria baicalensis Georgi）在传统东方医学中被誉为“黄金草本”。其核心多酚黄酮类活性成分——黄芩苷（Baicalin），在《Journal of Investigative Dermatology》、《Free Radical Biology and Medicine》等多项国际顶级SCI学术期刊中，被证实具有卓越的清除ROS、抑制MMPs酶活以及广谱紫外线防护的药理活性。 然而，在现代皮肤科学与高端化妆品应用中，未修饰的黄芩苷面临着“体外数据华丽，体内效果平庸”的转化鸿沟： 强结晶与极差的水/油溶解度： 导致其在化妆品乳液或精华体系中极易析出，无法保持高浓度游离态。 理化极度不稳定性： 含有多个易被氧化的酚羟基，在光、热或微碱性配方中易褐变并产生异味。 生物利用度 (Bioavailability) 极低： 分子极性大，被致密的角质层（Stratum Corneum）构成的砖墙结构强力阻挡，极难透皮进入真皮层发挥基因级靶向作用。 PuriPharm浦瑞生物医药：NanoActive®靶向智能递送解决方案 结合仿生医学与纳米流体动力学，PuriPharm采用专有NanoActive®包裹技术，构建了高度类似人类细胞膜结构的脂质囊泡（Vesicles），将高纯度黄芩苷精准且稳定地镶嵌于两亲性纳米双分子层中。 这一突破性技术彻底打破了黄芩苷的物理屏障，实现了高溶解、高稳定、靶向深透、长效缓释的四重系统级飞跃。 2. 核心作用机制 (MoA)：直击细胞衰老之源 依托NanoActive®载体高效的跨膜融合优势，黄芩苷得以在活细胞内达到有效治疗浓度，并在三大前沿抗衰老通路中发挥关键的调控作用： 2.1 靶向激活端粒酶 (Telomerase)，守护DNA末端生命线 诺贝尔生理学或医学奖研究表明，细胞复制性衰老受控于染色体末端的“生物钟”——端粒（Telomeres）。紫外线（UV）与持续的氧化应激会加速端粒急剧缩短，导致细胞不可逆的衰老（Senescence）。 TERT 基因上调： NanoActive® BAICALIN 能够深入细胞核，特异性激活或维持**端粒酶逆转录酶（TERT）**的表达水平。 解救 G1 期阻滞： 显著下调由于DNA损伤诱导的衰老核心开关基因p53和 p16INK4a，使陷入休眠的衰老细胞重获分裂与自我更新能力，从基因底层拨慢时间。 2.2 逆转 SASP (衰老相关分泌表型) —— 细胞级“Senomorphics” 在抗衰医学中，清除或改变衰老细胞分泌的毒性因子（SASP，如IL-6, IL-8, MMPs）是当前最热门的策略。 NanoActive® BAICALIN表现出强大的“Senomorphics（衰老表型调节剂）”活性。它能强效阻断NF-κB炎症信号通路，切断SASP级联反应对周围健康细胞外基质（ECM）的“传染性破坏”，保护I型和III型胶原蛋白网络。 2.3 唤醒 Nrf2/ARE 抗氧化主开关 突破了传统抗氧化剂（如VC、VE）1:1消耗性清除自由基的局限，NanoActive® BAICALIN充当了细胞内源性防御机制的“启动钥匙”。通过解离Keap1-Nrf2复合体，促使Nrf2入核并结合ARE序列，呈指数级放大内源性抗氧化酶群（SOD, CAT, GSH-Px）的表达。 3. 卓越的科学数据 (Scientific Efficacy)：以数据定义抗老极限 3.1 纳米靶向递送与动力学 (Kinetics & Delivery) 实验A：HaCaT细胞内化效率(Cellular Internalization) 利用荧光探针（Coumarin-6）结合流式细胞术与共聚焦显微镜检测。 结果：孵育2小时后，NanoActive®组的细胞内绝对荧光强度是未包裹游离黄芩苷组的4.2倍。仿生脂质体通过内吞作用（Endocytosis）无缝融合，实现了高效的“靶向空投”。 实验B：Franz扩散池透皮与Higuchi缓释模型 透皮率(Penetration)：24小时累积穿透猪耳表皮到达接收液的黄芩苷含量，NanoActive® BAICALIN是普通黄芩苷原料的8.5倍。 释放动力学(Release Profile)：释放曲线精准契合Higuchi扩散方程(R² > 0.98)，呈典型的骨架型缓释特征，长达24小时平稳释放，避免血药浓度“峰谷效应”，确保持久温和有效。 3.2 体外与离体全层皮肤模型 (In Vitro & 3D Ex Vivo) 实验C：TRAP法测定成纤维细胞端粒酶活性保护 将人原代成纤维细胞暴露于UVA光损伤模型下。 结果：UVA导致成纤维细胞端粒酶活性下降至正常组的31.2%。预处理NanoActive® BAICALIN后，端粒酶活性恢复至63.9%，证实了其对TERT机制的直接保护作用。 实验D：3D全层人体皮肤模型(3D Full-Thickness Skin Model)重塑 在重建的3D皮肤模型上连续滴加测试物7天。 结果：组织切片H&E染色与免疫荧光显示，对比对照组，NanoActive® BAICALIN处理组的表皮厚度增加17%，真皮层中胶原前体（Pro-collagen I）的荧光表达强度提升145%，真皮-表皮交界处（DEJ）结构更加致密起伏。 3.3 体内临床评估 (In Vivo Clinical Efficacy) 研究设计：随机、双盲、安慰剂对照临床试验。35名35-55岁存在中度光老化及皱纹的女性，半脸涂抹含2% NanoActive® BAICALIN的基础乳霜，每日2次，持续56天。仪器评估包含VISIA®-CR, Cutometer®,及高频皮肤超声。 临床核心数据： 1.真皮致密度跃升(Skin Density via Ultrasound)：使用20 MHz高频超声扫描（测量真皮层超声回声低/高密度区比例）。使用56天后，真皮层致密度（SLEB区域减少）显著增加19.3%，证明胶原网络得到实质性重塑。 2.深度抗皱与平滑(Wrinkle Reduction)：眼角鱼尾纹最大深度（Rz）减少22.4%，粗糙度（Ra）下降16.5%。 3.强效舒缓与抗炎性衰老(Erythema Index)：皮肤红斑指数（Erythema Index）在14天即出现显著下降（-11%），56天累计下降18%，临床验证了其阻断SASP带来的微炎症舒缓功效。 4. 技术优势与配方开发指南 (Formulation Guidelines) NanoActive® BAICALIN是为追求极致功效的高端护肤品而生的“即插即用”型生物活性物。 INCI Name /中文INCI：Scutellaria Baicalensis Root Extract黄芩（SCUTELLARIA BAICALENSIS）根提取物 外观物理形态：浅黄色至棕黄色半透明纳米流体。 粒径特征(Particle Size)：10 nm -100 nm (DLS检测，PDI < 0.2)。极小的粒径是其外观透明及深透皮的核心。 卓越的配方兼容性： 完美分散于水相，永不结晶析出。 宽广的pH耐受区间(pH 4.0 – 7.5)。 操作极简：无需加热，可于冷配体系直接加入水相；在热配乳化体系中，建议于均质冷却后（< 45℃）添加。 极端稳定性挑战(Stability Challenge)：在40℃恒温及5000 Lux光照培养箱中进行3个月加速测试。NanoActive® BAICALIN中的黄芩苷有效保留率> 95%，且外观零褐变、零异味（注：未包裹黄芩苷在同等条件下15天内即发生严重降解与变色）。 市场定位与应用领域(Applications & Claims)： 推荐添加量：日常维稳抗初老(0.5% – 2.0%)；靶向端粒酶、密集抗皱与光损伤修复(2.0% – 5.0%)。 概念宣称：端粒酶守护者、细胞寿命延长、Senolytics衰老清道夫、光老化逆转、无损深透递送。 适用剂型：高端抗衰面霜、基因修护基底精华、高能抗氧防晒液、微针/光电术后促愈合精华、高奢头皮抗衰防脱原液。 NanoActive® BAICALIN——国际前沿细胞级护肤的底层引擎 由PuriPharm浦瑞生物医药 研发与制造。结合大分子递送动力学与系统生物医学，重塑时间，解锁皮肤不老之秘。 Tagged 保湿, 嫩肤, 抗皱. [NanoActive® BAICALIN 端粒酶活化技术：重新定义细胞寿命] 黄金之根：黄芩 (Scutellaria)——草本抗衰的瑰宝 黄芩 (Scutellaria baicalensis Georgi) 是传统草本医学中最重要的药用植物之一。其根部因色泽金黄且具有极高的药效，被称为“黄金之根”。 标准化成分： 高纯度黄芩苷 (Baicalin) 核心药理： 抗自由基、抗炎、光保护 传统背景： 数千年的安全性验证，现代科研深度背书 黄芩苷 (Baicalin) 分子特性 细胞衰老：不可避免的生命局限？ 生命的时钟：端粒 (Telomeres) 诺贝尔生理学或医学奖背后的科学 发现端粒和端粒酶如何保护染色体： 2009年诺贝尔奖授予了 Elizabeth Blackburn 等三位科学家。这项发现确立了端粒在衰老过程中的核心地位。NanoActive® BAICALIN 的研发灵感正是源于这一尖端科学，致力于在化妆品领域应用端粒酶激活技术。 NanoActive®：解决传统痛点 体外实验：提升成纤维细胞寿命 分子机制：调节衰老相关基因 对抗光老化：UVA 损伤修复 体内功效研究 (In Vivo) 体内数据：皮肤微纹理重塑 紧致度与弹性的显著改善 全方位逆转细胞时钟 皮肤科研究：免疫调节与屏障 配方师的理想选择 护肤产品应用建议 安全性与质量控制 (Quality) 开启细胞层面的逆龄之旅 NanoActive® BAICALIN 纳米包裹黄芩苷不仅是一个原料，更是端粒酶科学在现代护肤中的完美落地。通过浦瑞生物领先的纳米技术，黄芩苷焕发出前所未有的生命力。

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상품명

NanoActive™ BAICALIN (리포좀)

복합물상품명

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공급사

1곳

제조사

PuriPharm

종류

Actives

용도

Anti-aging/Wrinkle Care, Antioxidant

인증·등록

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구성 성분 (1)

공급사 (1)

규격 및 사용 정보

INCI

Scutellaria Baicalensis Root Extract

CAS 번호

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EC 번호

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원산지

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성상

Light yellow to brownish-yellow translucent nano-fluid.

용해성

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pH

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권장 사용량

0.5%–2.0%

보관 조건

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사용 기한

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포장 단위

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기술 문서 (TDS·SDS·COA)

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안전성 자료

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규제 자료

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Solubility

100% highly water-soluble for crystal-clear formulations.

Particle Size

10-100nm (DLS detection, PDI < 0.2). This ultra-small particle size is the core of its transparent appearance and deep transdermal penetration.