Tetrahydrofurfuryl alcohol is a primary alcohol that is methanol in which one of the hydrogens of the methyl group has been replaced by a tetrahydrofuran-2-yl group.
Definition
US FDA substance register · UNII XD95821VF9 · registered name TETRAHYDROFURFURYL ALCOHOL · single chemical substance
Tetrahydrofurfuryl alcohol is a primary alcohol that is methanol in which one of the hydrogens of the methyl group has been replaced by a tetrahydrofuran-2-yl group. It has a role as a protic solvent. It is a primary alcohol and a member of oxolanes.
Source: PubChem
Tetrahydrofurfuryl Alcohol is the cyclic alcohol that conforms to the formula:
Cosmetic roles
Safety & regulatory references
- Banned
- ASEAN · European Union · United Kingdom
Source: ASEAN Cosmetic Directive · EU Cosmetics Regulation · MFDS (Korea) cosmetic regulatory information · UK cosmetics regulations (OPSS)
Not classified under Korea’s toxic-substance GHS list · existing chemical substance
EU Cosmetics Regulation, Annex II (prohibited substances), entry 1576
Restriction II/1576 · Other restriction: ban substances that deplete the ozone layer
Source: EU CosIng ingredient list
More data — names, identifiers, properties, test records, literature
Official labels & definitions
JCIA labelling name テトラヒドロフルフリルアルコール: 本品は、次の化学式で表される環状アルコールである。
Source: JCIA labelling names (Japan)
Names & identifiers
- CAS No.chemical registry number
- 97-99-4
- EC No.EU chemical inventory number
- 202-625-6
- DTXSIDUS EPA chemical ID
- DTXSID1029128
- DTXCIDUS EPA compound ID
- DTXCID909128
- IUPAC
- (Oxolan-2-yl)methanol
- Molecular formula
- C5H10O2
- Molecular weight
- 102.133 g/mol
Measured properties
- Appearance
- Tetrahydrofurfuryl alcohol appears as a clear colorless liquid with a mild odor. Vapors are heavier than air. · CBI, Liquid
- Odour
- Mild odor · Odorless
- Boiling point
- 178 °C @ 760 mm Hg · 178.00 to 179.00 °C. @ 760.00 mm Hg
- Melting point
- Less than -80 °C · < -80 °C
- Solubility
- Miscible with water, alcohol, ether, acetone, chloroform, benzene · 1000 mg/mL at 25 °C
- Density
- 1.0544 @ 20 °C/20 °C · Relative density (water = 1): 1.05
- Viscosity
- 6.24 centipoises @ 20 °C · 6.24 cP (20 °C)
- Colour
- colourless
- Melting/freezing point
- &, lt, -80 ℃
- Initial boiling point and range
- 178 ℃
- Flash point
- 75 ℃
- Upper/lower flammability or explosive limits
- 9.7 / 1.5 %
- Vapour pressure
- 0.801 ㎜Hg (25 °C)
- Water solubility
- 100000 ㎎/ℓ (25 °C)
- Vapour density
- 3.522
- Relative density
- 1.0544 (@ 20 °C)
- n-Octanol/water partition coefficient (Kow)
- -0.11 ( at 20 °C)
- Auto-ignition temperature
- 282 ℃
- Molecular weight
- 102.15
Values measured on the substance itself. The KOSHA data are a reference for writing and reviewing safety data sheets, not a specification for a commercial raw material.
Source: PubChem · KOSHA safety data sheets (Korea)
What products actually use it for
What the 11 products reported to the US EPA with this ingredient use it for. Products outside cosmetics are included, so the top few rows are its main uses.
- Solvent6
- Flavouring and nutrient2
- Fragrance2
- Deodorizer1
Source: US EPA CompTox dashboard
Irritation and sensitisation studies
5 skin studies and 4 eye studies are on record.
The studies disagree (the most common conclusion covers 33%), so they do not establish that this ingredient is irritating. These tests are on the raw material itself; irritation at the amount in a finished product is a different question.
See all 9 studies
- Studies Indicate No Significant Irritation
skin irritation: in vivo · Screening · EPA OPP 81-5 (Acute Dermal Irritation) according to other guideline: Japanese Agricultural Chemicals Laws and regulations Testing Guidelines for Toxicology Studies published by the Society of Agricultural Chemical Industry, under the Ministry of Agriculture, Forestry and Fisheries according to - Not likely to be sensitizing
skin sensitisation: in vivo (LLNA) · Screening · according to OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay) - Classification not possible
Skin Sensitization · Screening - Category 2
Skin Irritation · Screening - Category 6.3B (Category 3)
Skin Irritation · Read Across - Category 6.4A (Category 2A)
Eye Irritation · Read Across - Severe Irritation
eye irritation: in vivo · Screening · EPA OPP 81-4 (Acute Eye Irritation) according to - Eye Irrit. 2
Eye Irritation · Authoritative - Category 2A
Eye Irritation · Screening
Source: US EPA CompTox dashboard
Related literature
Linked databases 23
- ASEAN Cosmetic Directive
- Australian Industrial Chemicals Inventory (AICIS)
- ChEBI
- EU CosIng ingredient list 2
- EU Cosmetics Regulation
- EU prohibited substances (Annex II)
- JCIA labelling names (Japan)
- Korea Cosmetic Association ingredient dictionary
- Korea toxic substances GHS register (NIER)
- KOSHA safety data sheets (Korea)
- MFDS (Korea) cosmetic ingredient register 2
- MFDS (Korea) cosmetic regulatory information
- NIST Chemistry WebBook
- PubChem 2
- Tlooto literature search 2
- UK cosmetics regulations (OPSS)
- UniChem cross-reference IDs
- US EPA CompTox dashboard 2
- US EPA DSSTox chemical database
- US FDA substance registration (GSRS)
- US FDA Unique Ingredient Identifier (UNII)
- Wikidata
- Wikipedia · English · Japanese · Chinese