NanoActive™ MN(리포좀)

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[NanoActive MN PRODUCT DATA SHEET] Manufacturer: PuriPharm Co. Ltd. 1. Product Overview NanoActive MN is an advanced, high-performance bioactive ingredient engineered specifically for premium skin and hair care formulations. Utilizing state-of-the-art nano-delivery technology, NanoActive MN features a specialized lipophilic tail that drastically improves skin penetration while minimizing the irritation and sensitization traditionally associated with unmodified nicotinic acid. Once delivered into the skin, it undergoes targeted conversion into Nicotinamide Adenine Dinucleotide (NAD+), a critical coenzyme that orchestrates cellular energy metabolism, DNA repair, and lipid synthesis, fundamentally reversing the age-related decline of skin and hair follicle vitality. 2. INCI & Chemical Information INCI Name: Myristyl Nicotinate Product Type: Nano-encapsulated Bioactive Agent 3. Technology Highlights PuriPharm Co. Ltd. leverages proprietary core technologies to ensure maximum efficacy: Nano Delivery System: Advanced nanotechnology ensures optimized bioavailability and targeted, deep-layer delivery of the active compound. Enhanced Penetration: The lipophilic modification facilitates superior transepidermal transportation. Targeted Action: Precisely targets local skin cells and hair follicles where esterase activity initiates the conversion process. Improved Stability: Formulated to protect the active core, ensuring long-term shelf-life and robust compatibility within complex cosmetic matrices. 4. Mechanism of Action: The NAD+ Pathway NAD+ levels natively decline by up to 50% by middle age, leading to compromised cellular repair and energy metabolism. NanoActive MN effectively addresses this: Enzymatic Cleavage: Upon penetration, native skin esterases selectively cleave the lipophilic tail of NanoActive MN. Conversion: The molecule is efficiently converted into the active coenzyme NAD+ via cellular synthetic pathways. Cellular Optimization: The synthesized NAD+ directly fuels mitochondrial energy generation, upregulates barrier lipid synthesis, and supports genomic (DNA) repair, combating oxidative stress and cellular senescence. 5. Proven Cosmetic Benefits & Efficacy Data NanoActive MN has demonstrated remarkable results across comprehensive clinical andin vitroevaluations: A. Profound Skin Barrier Repair Visual & Structural Improvement: Clinical studies demonstrate a 250% improvement in barrier function on facial skin and an 11% improvement on the forearm volar surface (at 5% use level). Epidermal Fortification: Induces a highly significant 70% increase in epidermal thickness (compared to a 13% increase in the control group). Tight Junction Enhancement: Upregulates ZO-1 protein expression (3.38-fold relative expression at 0.04 mg/mL), physically reinforcing the skin barrier. B. Anti-Aging & Cellular Renewal Accelerated Renewal: Safely accelerates skin cell renewal by reducing Dansyl turnover time and increasing Minimal Erythema Dose (MED) without inducing photosensitivity. Antioxidant Capacity: Exhibits excellent DPPH radical scavenging ability (6.10% maximum clearance at 0.3125%). C. Hair Follicle Vitality & Anti-Hair Loss Scalp Energy: Converts to NAD+ within the scalp, enhancing cellular ATP, stimulating follicle cell renewal, and actively neutralizing oxidative stress. Clinical Hair Improvement: Well-designed clinical trials confirm significant improvements in hair abundance, density, hair shaft thickness, and overall hair quality with zero reported adverse effects. D. Synergistic Efficacy with Retinoids Retinol Companion: When formulated alongside retinoic acid or its derivatives, NanoActive MN acts as a potent buffer—significantly reducing retinoid-induced irritation and Transepidermal Water Loss (TEWL) while amplifying overall anti-aging efficacy. 6. Formulation Guidance & Compatibility NanoActive MN is designed for seamless integration into modern cosmetic chemistry. Suggested Use Level: 0.2% – 5.0% Suitable Formulations: O/W and W/O Emulsion systems, Creams, Lotions, Serums, Essential Oils, Massage Oils, and Cleansing products. Ingredient Compatibility: Exhibits excellent compatibility with a wide array of cosmetic raw materials including UV filters, emollients, humectants, natural oils, potent antioxidants, emulsifiers, thickeners, and retinoids. Minimal degradation is observed even in complex formulation matrices. 7. Recommended Applications Advanced Facial Care: Anti-aging creams, barrier-repair lotions, and high-potency cellular regeneration serums. Eye Care: Non-irritating eye creams and serums targeting fine lines and delicate skin reinforcement. Hair & Scalp Care: Anti-hair loss treatments, scalp energizing tonics, and hair density serums. Color Cosmetics: Functional lipsticks, lip glosses, eyeliners, and mascaras requiring bioactive support. 8. Storage, Stability, and Handling Long-Term Stability: Demonstrates exceptional stability; viable for 24 months at room temperature in various formulations. Withstands accelerated stability testing (3 months at 40°C). Storage Conditions: Store in a cool, dry environment between 4°C and 25°C. Protect from direct sunlight and moisture. Keep the original container tightly sealed when not in use. Disclaimer:The information contained in this document is provided in good faith and is based on our current laboratory data and technical knowledge. It is intended for informational purposes only. Formulators are responsible for ensuring the stability, safety, and legal compliance of their final consumer products. PuriPharm Co. Ltd. makes no warranties, expressed or implied, regarding the use of this product. [NanoActive MN Advanced Bioactive Ingredient for Skin and Hair Care] Product Overview INCI Name The INCI name is MyristylNicotinate, which is the standardized name in the cosmetic industry. Product Type It is an advanced bioactive ingredient specifically designed for skin and hair care products. Key Feature It can convert to NAD + in skin cells, improving penetration and reducing irritation compared to regular nicotinic acid. Features & Applications Applications Mechanism of Action The NAD + pathways and conversion process ofNanoActiveMN NAD+ Pathways NAD+ Importance NAD + is essential for energy generation in mitochondria, lipid synthesis, DNA damage repair, and maintaining mitochondrial function and telomere length. NAD+ Synthesis Pathways There are three main pathways: the de novo pathway starting from tryptophan, the Preiss – Handler pathway using nicotinic acid, and the salvage pathway recycling NAD + metabolites. NAD+ and Skin Health NAD + is critical for cellular repair, energy metabolism, and combating age – related decline in skin. Its levels decrease by 50% by middle age. NanoActiveMN Conversion Efficacy Data Barrier Repair： Efficacy data on skin barrier repair Anti – aging & Antioxidant 1. DPPH Radical Scavenging The maximum clearance is 6.10% at a concentration of 0.3125%, showing its antioxidant ability. 2. ZO – 1 Protein Expression At 0.04 mg/mL concentration, there is a 3.38 – fold relative expression of ZO – 1 protein. 3. Synergistic Effects with Retinoic Acid It reduces irritation, enhances efficacy, and reduces water loss when used with retinoic acid. Hair Loss Prevention 1. Clinical Study Design A well – designed study was conducted to evaluate the efficacy ofNanoActiveMN on hair loss prevention. 2. Study Results There was a significant improvement in hair abundance, density, quality, and thickness, with no adverse effects reported. 3. Mechanism of Action It converts to NAD + in the scalp, enhancing cellular energy, improving barrier function, stimulating hair follicle cell renewal, and reducing oxidative stress. Company Introduction PuriPharmCo. Ltd. 1. Company Background Specialized in bioactive ingredients, founded by industry experts and has global partnerships with research institutions. 2. Quality & Manufacturing Strict quality control standards, state – of – the – art manufacturing facilities, and sustainable practices are in place. 3. R&D Capabilities An expert technical team with PhD – level scientists and advanced laboratory facilities for cosmetic ingredient development. Core Technologies Nano Delivery：Advanced nanotechnology for enhanced bioavailability and targeted delivery of active ingredients. Targeted Action：Allows for targeted action of ingredients at specific skin or hair sites. Enhanced Penetration：Improves the penetration of ingredients into the skin for better efficacy. Improved Stability： Ensures the stability of formulations during storage and use. Formulation Stability Stability information under different conditions 1. 24 – months Stability at Room Temperature NanoActiveMN shows good stability in various formulations at room temperature for 24 months. 2. 3 – months Stability at 40℃ It has 3 – months stability at 40℃ in accelerated testing. 3. Minimal Degradation in Complex Formulations There is minimal degradation in complex cosmetic matrices, ensuring long – term effectiveness. Storage & Compatibility Storage Conditions： Store at 4 – 25℃ in a dry environment, protect from light, and keep the container tightly sealed. Tested Formulations It has been tested with various ingredients such as UV filters, emollients, humectants, natural oils, etc. Ingredient Compatibility Compatible with a wide range of cosmetic ingredients, including retinoids, antioxidants, emulsifiers, and thickeners. [Nanao Active MN Overview] If you are Chinese, or if reading in Chinese is more convenient for you, you can access the Chinese product introduction PPT through this link.纳米包裹肉豆蔻醇烟酸酯 Nanao Active MN Overview ——Advanced Bioactive Ingredient for Skin and Haire Care

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상품명

NanoActive™ MN(리포좀)

복합물상품명

미확인

공급사

1곳

제조사

PuriPharm

종류

Actives

용도

Anti-aging/Wrinkle Care

인증·등록

NMPA

구성 성분 (1)

공급사 (1)

규격 및 사용 정보

INCI

Myristyl Nicotinate

CAS 번호

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EC 번호

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원산지

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성상

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용해성

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pH

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권장 사용량

0.2%–5.0%

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포장 단위

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