NanoActive™ Phloretin (리포좀)

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[NanoActive™ Phloretin Redefining Efficacy with Advanced Nano-Delivery Technology] 1. Product Overview Phloretin, an extraordinary dihydrochalcone polyphenol derived from the root bark of Malus domestica (apple tree), is celebrated for its multi-functional benefits: remarkable tyrosinase inhibition, potent radical scavenging, and cellular DNA protection. However, traditional crystalline Phloretin is notoriously difficult to formulate due to poor water solubility, high oxidation susceptibility, and inability to penetrate the stratum corneum barrier effectively. PuriPharm introduces NanoActive™ Phloretin—powered by our proprietary Advanced Nano-Delivery System Technology. By encapsulating Phloretin within a sub-50nm nanostructured lipid matrix, we have unlocked its full potential, transforming nature's most potent antioxidant into a stable, highly bioavailable formulation solution. 2. Key Benefits at a Glance Breakthrough Bioavailability: Amphiphilic architecture enables seamless delivery across skin barriers. Enhanced Stability: Protects the active payload from premature oxidation and degradation. Formulation Freedom: Cold-processable, 100% water-dispersible, and prevents recrystallization or color shift. Unmatched Potency: Delivers 94% radical scavenging efficiency and powerful tyrosinase inhibition (IC50 = 37.5 μmol/L). 3. The Science Behind the Innovation Advanced Whitening & Melanin Regulation Acts at the cellular level to inhibit tyrosinase activity. Fades post-inflammatory hyperpigmentation (PIH) and dramatically improves skin luminosity (L* value) without irritation. Broad-Spectrum Antioxidant Matrix Neutralizes reactive oxygen species (ROS) far more effectively than crystalline alternatives. The nano-delivery system ensures max dispersion in aqueous environments, achieving 94% scavenging efficiency—outperforming standard Vitamin C. Acne Mitigation & Sebum Control Targets sebaceous glands to reduce excess lipogenesis while inhibiting pro-inflammatory markers (PGE2, COX-2). Promotes a long-lasting matte finish and accelerates blemish recovery. Deep Cellular DNA Defense Shields cellular DNA from UV-induced Thymine Dimer formation and prevents the degradation of collagen by blocking MMP-9 expression, addressing the root causes of photoaging. 4. Applications & Guidelines INCI Name: Phloretin, Phospholipids, Caprylic/Capric Triglyceride, Glycerin, Water Recommended Use Level: 0.5% – 2.0% Optimal pH: 4.5 – 6.5 Applications: Premium skin brightening serums, daily antioxidant defense lotions, anti-acne spot treatments, and cellular repair night creams. Formulator's Note: Ideal for cold-process formulations (add < 45°C). Compatible with high-clarity clear serums, O/W emulsions, and gels. 5. Storage & Safety Storage Conditions: Store between 4°C and 25°C. Protect from direct light and localized thermal sources. No strict cold chain required. Safety Profile: 0.0% irritation index in patch testing. Non-phototoxic, non-sensitizing, and GMO-free. [NanoActive PHLORETIN] PURIPHARM: MOLECULAR EXCELLENCE Bridging Science & Formulations We empower global personal care brands through two core pillars of innovation, ensuring biological efficacy meets precise spatial delivery. NANOACTIVE® ARCHITECTURE PHLORETIN: THE APPLE EXTRACT THE SOLUBILITY CHALLENGE NANOACTIVE® PHLORETIN LIQUID PRODUCT SPECIFICATIONS ANTIOXIDANT EFFICACY ANTI-INFLAMMATORY ACTION LUMINOSITY & CLARITY Biological Shield Beyond traditional UV filters, NanoActive Phloretin prevents cellular damage at the DNA level: Prevents Thymine Dimer formation. Reduces p53 protein expression (Stress marker). Preserves Langerhans Cells for immune defense. FORMULATOR'S ADVANTAGE [NanoActive Phloretin] Advanced Nano-Delivery System for Enhanced Bioavailability & Skin Penetration 1.PRODUCT DESCRIPTION NanoActive Phloretin is a highly advanced, water-dispersible nano-structured delivery system developed specifically for high-end cosmetic and dermatological formulations. Phloretin, a natural dihydrochalcone polyphenol primarily extracted from the root bark of apple trees (Malus domestica), possesses extraordinary biological properties including potent tyrosinase inhibition, broad-spectrum free radical scavenging, anti-inflammatory effects, and cellular DNA protection. Despite its remarkable therapeutic potential, raw crystalline Phloretin faces significant formulation constraints in personal care applications due to its severe lipophilicity, poor aqueous solubility, susceptibility to oxidation, and limited capacity to cross the thermodynamic barrier of the stratum corneum. PuriPharm overcomes these challenges by utilizing an innovative multi-lamellar liposomal architecture. By encapsulating Phloretin into nanostructured lipid matrices (Particle Size < 50 nm), the system dramatically amplifies active molecule stability, optimizes delivery kinetics, and increases biological skin absorption without the use of irritating organic solvents or high alcohol levels. 2.TECHNICAL SPECIFICATIONS 3. BIOLOGICAL EFFICACY & MECHANISMS 3.1 Advanced Melanin Regulation & Skin Whitening NanoActive Phloretin acts as a highly effective inhibitor of mammalian tyrosinase, the rate-limiting enzyme in melanogenesis. It downregulates the conversion of L-tyrosine to L-DOPA, suppressing melanin synthesis at a cellular level. Clinical data exhibits an ultra-low half-maximal inhibitory concentration (IC50 = 37.5 μmol/L), significantly outperforming traditional agents like Kojic Acid and Arbutin. The nano-delivery system ensures active transport into basal layer melanocytes, effectively fading post-inflammatory hyperpigmentation (PIH), evening out skin tone, and enhancing overall skin translucency and L* luminosity values. 3.2 Comprehensive Antioxidant & Radical Scavenging Architecture The polyphenolic structure of Phloretin offers powerful electron-donating properties to neutralize destructive reactive oxygen species (ROS). In comparative DPPH radical scavenging assays executed within aqueous environments, standard crystalline Phloretin displays suboptimal performance due to poor phase dispersion. Under identical aqueous test conditions: Pure Crystalline Phloretin: 42% free radical scavenging capacity. L-Ascorbic Acid (Vitamin C): 88% free radical scavenging capacity. NanoActive Phloretin: 94% radical scavenging efficiency. This distinct upregulation is driven by the amphiphilic lipid membrane shell, which maximizes contact surface area with free radicals in the water phase while preserving the inner molecular integrity of the active polyphenol. 3.3 Sebum Regulation & Anti-Acne Efficacy NanoActive Phloretin modifies the sebaceous microenvironment through multi-pathway mechanisms. It restricts excessive sebocyte lipogenesis, yielding a quantifiable reductions in sebum output and a long-lasting matte skin finish within 4 weeks. Concurrently, its strong anti-inflammatory properties inhibit Prostaglandin E2 (PGE2) secretion and cyclooxygenase-2 (COX-2) expression, yielding a 29.1% reduction in inflammatory pustules and acne-induced erythema. 3.4 Deep Cellular DNA Shield & Photo-Aging Defense Beyond traditional cosmetic benefits, NanoActive Phloretin provides genuine biological protection against ultraviolet (UV) irradiation. It enters viable epidermal layers to prevent the formation of cyclobutane pyrimidine dimers (Thymine Dimers) within cellular DNA. It dampens ultraviolet-induced p53 protein expression (a critical cellular stress indicator) and strictly blocks the up-regulation of Matrix Metalloproteinase-9 (MMP-9), thus preventing the structural breakdown of dermal collagen matrices and mitigating chronic photo-induced aging. 4. FORMULATION & PROCESSING GUIDELINES Formulator's Edge: Unlike conventional crystalline Phloretin which is prone to recrystallization, sedimentation, and sudden color shifts, NanoActive Phloretin features excellent structural stability and effortless integration into diverse cosmetic chassis. Recommended Use Level: 0.5% – 2.0% depending on the targeted performance profile (e.g., intensive whitening vs. daily antioxidant defense). Optimal Formulation pH: Safe and stable across a broad pH span of 3.0 to 6.5. Optimum shelf stability is achieved between pH 4.5 and 6.5. Processing Temperature: Cold processable. The product should preferably be incorporated during the final phase of manufacturing (cool-down stage) at temperatures below 45°C. Incorporation Technique: Directly add to the aqueous phase under gentle stirring. Compatible with surfactant systems, hydrogels, O/W emulsions, and clear transparent serums without inducing recrystallization. 5. STORAGE, PACKAGING & SHELF LIFE Packaging: Available in 1 kg, 5 kg, and 25 kg food-grade, UV-shielded polyethylene containers. Storage Conditions: Store in the original sealed container at temperatures between 2°C and 25°C (refrigerated storage recommended for maximum lifecycle shelf-life). Keep away from direct sunlight, moisture, and localized heat sources. Shelf Life: 12 months from the date of manufacture when stored strictly in compliance with recommended conditions. 6. REGULATORY & SAFETY PROFILE Safety Assessment: Non-irritating to human skin (0.0% irritation index in patch testing). Non-phototoxic, non-sensitizing, and free from genetically modified organisms (GMO-free). Compliance: INCI registered components. Globally compliant with EU, US FDA, and China NMPA safety technical standards for cosmetics. [NanoActive™ Phloretin 纳米包裹根皮素以“新型纳米传输系统技术”重塑功效巅峰] 1. 产品概览 (Product Overview) 根皮素（Phloretin）提取自苹果树（Malus domestica）根皮，是一种卓越的天然二氢查耳酮类多酚，因其在强效抑制酪氨酸酶、广谱清除自由基及保护细胞DNA方面的卓越表现而备受推崇。然而，传统结晶态根皮素水溶性极差、极易氧化变色，且难以有效穿透角质层的热力学屏障，这极大地限制了其在高端个人护理品中的应用。 PuriPharm 研发的 NanoActive™ Phloretin，搭载了我们独有的“新型纳米传输系统技术”。通过将根皮素精准包裹在平均粒径小于 50nm 的纳米脂质矩阵中，我们成功释放了其全效潜能，将自然界最强效的抗氧化剂之一转化为高稳定性、高生物利用度的水相配方解决方案。 2. 核心优势一览 (Key Benefits) 突破性的生物利用度：两亲性纳米架构帮助活性成分无缝穿透皮肤屏障，实现精准递送。 卓越的配方稳定性：犹如隐形护盾，防止核心分子提前氧化、降解与变色。 极高的配方宽容度：支持冷工艺操作，100% 水溶，在配方中不结晶、不析出。 无与伦比的功效表现：提供高达 94% 的水相自由基清除率，以及极强的美白调控力（IC50 = 37.5 μmol/L）。 3. 创新背后的科学 (The Science) 进阶黑色素调控与精准焕亮 在细胞源头阻断酪氨酸酶活性。高效淡化炎症后色素沉着（PIH），显著提升肌肤透明度与 L* 亮度值，且温和无刺激。 全矩阵抗氧化防御系统 在水相环境中的清除效率远超传统结晶根皮素，甚至优于纯维C，将强大的电子供体能力转化为对活性氧（ROS）的精准捕获，清除率高达 94%。 皮脂微生态调节与抗炎修护 靶向调控皮脂腺微环境，减少过度脂肪生成，同时抑制促炎标记物（PGE2, COX-2）。改善油光，维持长效哑光质感，加速痘印修护与泛红消退。 深层细胞 DNA 盾牌与抗光老 在基底层提供真正的生物学防晒保护，阻断紫外线诱导的胸腺嘧啶二聚体形成，并抑制 MMP-9 表达，从根源防止胶原蛋白降解与慢性光老化。 4. 配方应用指南 (Applications & Guidelines) INCI 名称：Phloretin, Phospholipids, Caprylic/Capric Triglyceride, Glycerin, Water 建议添加量：0.5% – 2.0% 最适配方 pH 值：4.5 – 6.5 适用范围：高端美白提亮精华、日常抗氧防御乳液、抗痘点涂修护凝胶、细胞级抗老晚霜。 配方师操作提示：非常适合冷工艺（推荐 <45°C 下添加）。与高透明度水感精华、水包油乳液体系等均可完美兼容。 5. 存储与安全性 (Storage & Safety) 存储条件：储存于 4°C – 25°C 的宽温域环境。须避光并远离局部热源。无需严苛的冷链仓储，物流极为便利。 安全及合规性：人体斑贴测试表明刺激指数为 0.0%（极致温和）。无光毒性、无致敏性，不含转基因成分（GMO-free）。

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NanoActive™ Phloretin (리포좀)

복합물상품명

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공급사

1곳

제조사

PuriPharm

종류

Actives

용도

Nourishing, Moisturizing, Antioxidant

인증·등록

NMPA

구성 성분 (5)

공급사 (1)

규격 및 사용 정보

INCI

Phloretin, Phospholipids, Caprylic/Capric Triglyceride, Glycerin, Water

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성상

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용해성

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pH

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권장 사용량

0.5%–2.0%

보관 조건

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포장 단위

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기술 문서 (TDS·SDS·COA)

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Shelf Life

12 months from the date of manufacture when stored strictly in compliance with recommended conditions.