Is it true that you shouldn’t use niacinamide and vitamin C together?
This claim often spread from old laboratory conditions (high temperatures, etc.). There’s limited evidence that using typical modern skincare products together is a problem.
However, there are other reasons you might actually experience discomfort.
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Pure vitamin C (ascorbic acid) is highly acidic, so some people may feel stinging.
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High-concentration niacinamide may also cause redness in some people.
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If you start using both at the same time, it can be hard to tell which one is causing it.
Which of the following is closest to a combination to be most careful with when used together?
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That’s right. There’s no need to make a blanket claim that “using them together neutralizes each other.” In general, concentration, formulation, and how your skin reacts are more practical factors than how well the two ingredients work together.
Products containing ascorbic acid, a form of pure vitamin C, have an acidic formula and may tingle when applied, while high-concentration niacinamide can also irritate sensitive skin. If you’re new to them, start with one product at a time, leaving a few days between them. If you want to use both, you can use them morning and evening, or use one every other day. If you include them in the same routine, apply the thinner formula first after cleansing, then finish with a moisturizer.
If the stinging continues or redness is pronounced, pause both for a while. Once your skin has settled, check each product one at a time to help identify the cause. Vitamin C derivative products may have different formulation properties from pure ascorbic acid, so check the product information as well.
Editor’s note: Pure vitamin C (ascorbic acid) products are sensitive to air and light, so consider replacing them if they turn a deep orange or brown color.