sh-Polypeptide-111 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is a synthesized copy of the human gene which codes for Disintegrin and Metalloproteinase Domain-containing Protein 15 used as such or adapted to the production host. It contains a maximum of 863 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.